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Technical documents: SDS CoA Datasheet

Product overview

Name (R,S)-AMPA
Purity >98%
Description Prototypic AMPA receptor agonist
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AMPAR mediated whole cell current in response to RS-AMPA
(R,S)-AMPA: Scientist Approved
(R,S)-AMPA product vial image | Hello Bio

Biological Data

Biological description

Prototypic AMPA receptor agonist (EC50 = 11 μM). (S)-AMPA is the active enantiomer form.

Application notes

The AMPA receptor agonist (R,S)-AMPA is typically used at concentrations of 1-100 µM. At 10 µM, (R,S)-AMPA from Hello Bio induces a large depolarising current. This depolarising current was occluded in the presence of the AMPA receptor antagonist NBQX (20µM). (See Fig 1 above).

#Protocol 1: (R,S)-AMPA protocol

  • Whole cell voltage clamp recordings of CA1 pyramidal neurons from the rat hippocampal brain slice.
  • Neurons were held at -60 mV and continuously perfused with aCSF in the presence of the GABA receptor antagonist gabazine (20µM).
  • AMPA currents were evoked via applying (R,S)-AMPA directly to the recording chamber during continuous perfusion.
  • To test the selectivity of (R,S)-AMPA to AMPA receptors, the experiment was repeated within the same neuron in the presence of the AMPA receptor antagonist NBQX (20 µM)
  • Under these conditions (R,S)-AMPA failed to induce a depolarising current.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in water (10mM, gentle warming)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name (RS)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
Molecular Weight 186.17
Chemical structure (R,S)-AMPA  [77521-29-0] Chemical Structure
Molecular Formula C7H10N2O4
CAS Number 77521-29-0
PubChem identifier 1221
Source Synthetic
InChi InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)
MDL number MFCD00213388
Appearance White solid

References for (R,S)-AMPA

References are publications that support the biological activity of the product
  • The AMPA receptor binding site: focus on agonists and competitive antagonists.

    Stensbøl TB et al (2002) Curr Pharm Des 8(10) : 857-72.
  • Willardiines differentiate agonist binding sites for kainate- versus AMPA-preferring glutamate receptors in DRG and hippocampal neurons.

    Wong LA et al (1994) J Neurosci 14(6) : 3881-97.
  • Activation and desensitization of AMPA/kainate receptors by novel derivatives of willardiine.

    Patneau DK et al (1992) J Neurosci 12(2) : 595-606.

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