Product overview
Name | DNQX |
Description | Selective, competitive AMPA / kainate receptor antagonist |
Purity | >98% |
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Biological Data
Biological description | DNQX is a selective and competitive AMPA and kainate receptor antagonist. DNQX allso acts as partial AMPA agonist in the presence of γ2 transmembrane AMPA receptor regulatory proteins (TARP) subunit. DNQX is also a neuroleptic agent that displays pro-oxidant activity. Water soluble DNQX disodium is also available. |
Application notes | DNQX antagonizes the actions of glutamate at AMPA receptors. It is commonly used to reduce excitatory post synaptic currents (EPSC) and is commonly used at 10 μM. DNQX disodium salt from Hello Bio completely blocks both spontaneous and evoked EPSCs at 10 μM, with concentrations of 1 μM also effective (see Fig 1 above).
#Protocol 1: Evoked and spontaneous excitatory post synaptic currents (EPSCs)
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Solubility & Handling
Storage instructions | Room temperature |
Solubility overview | Soluble in DMSO (100mM) |
Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
Chemical name | 6,7-Dinitroquinoxaline-2,3-dione |
Molecular Weight | 252.14 |
Chemical structure | |
Molecular Formula | C8H4N4O6 |
CAS Number | 2379-57-9 |
PubChem identifier | 3899541 |
SMILES | C1=C2C(=CC(=C1[N+](=O)[O-])[N+](=O)[O-])NC(=O)C(=O)N2 |
Source | Synthetic |
InChi | InChI=1S/C8H4N4O6/c13-7-8(14)10-4-2-6(12(17)18)5(11(15)16)1-3(4)9-7/h1-2H,(H,9,13)(H,10,14) |
InChiKey | RWVIMCIPOAXUDG-UHFFFAOYSA-N |
MDL number | MFCD00069257 |
Appearance | Pale yellow solid |
References for DNQX
References are publications that support the biological activity of the product
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Redox properties and prooxidant cytotoxicity of a neuroleptic agent 6,7-dinitrodihydroquinoxaline-2,3-dione (DNQX).
Šarlauskas J et al (2013) Acta Biochim Pol 60(2) : 227-31. -
Selective excitatory actions of DNQX and CNQX in rat thalamic neurons.
Lee SH et al (2010) J Neurophysiol 103(4) : 1728-34. -
TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists.
Menuz K et al (2007) Science 318(5851) : 815-7. -
Pharmacological characterization of glutamatergic agonists and antagonists at recombinant human homomeric and heteromeric kainate receptors in vitro.
Alt et al (2004) Neuropharmacology 46(6) : 793-806
Publications
These publications cite the use of DNQX purchased from Hello Bio:
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PTC-174, a positive allosteric modulator of NMDA receptors containing GluN2C or GluN2D subunits
Yi F et al (2020) Neuropharmacology 25 : 107971PubMedID: 31987864