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Designer receptors exclusively activated by designer drugs (DREADDs) are genetically engineered GPCRs that are activated by physiologically inert synthetic small molecules (designer drugs) but not their endogenous ligand. Read our DREADDs mini-review or for practical advice on using these ligands in the lab see Stability of Water-Soluble DREADD Ligands in Solution: A Technical Review and Clozapine N-Oxide (freebase) - a technical review on stability, solubility and use in the lab).
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MOG (35-55) (HB5273)
Description:Myelin oligodendrocyte glycoprotein fragment. Induces experimental multiple sclerosis-like disease.
Purity:>95%
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Pam3CSK4 (HB3428)
Description:TLR1/TLR2 agonist and potent NF-κB activator. Induces cytokine production.
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uPSEM792 hydrochloride (HB8542)
Description:Ultrapotent PSEM agonist for PSAM4-GlyR and PSAM4-5HT3. Brain penetrant.
Purity:>99%
