Product overview

Name LY 354740 hydrate
Purity >95%
Description Potent, selective group II receptor agonist
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Biological Data

Biological description Potent and selective group II receptor agonist (EC50 values are 5.1 and 24.3 nM for mGlu2 and mGlu3 receptors respectively). Displays little activity at mGlu1a, 4, 5a and 7 receptors. Shows anxiolytic, anti-addictive and antipsychotic properties.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in NaOH(aq) (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use



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Chemical Data

Purity >95%
Chemical name (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylicacid
Molecular Weight 203.19
Chemical structure LY 354740 hydrate  [176199-48-7] Chemical Structure
Molecular Formula C8H11NO4.H2O
CAS Number 176199-48-7
PubChem identifier 213056
SMILES N[C@]1([C@@](O)=O)[C@@]2([H])[C@@]([C@@H]2[C@](O)=O)([H])CC1
InChi InChI=1S/C8H11NO4/c9-8(7(12)13)2-1-3-4(5(3)8)6(10)11/h3-5H,1-2,9H2,(H,10,11)(H,12,13)/t3-,4-,5-,8-/m0/s1
MDL number MFCD04113018

References for LY 354740 hydrate

References are publications that support the biological activity of the product
  • In vitro and in vivo evidence for a lack of interaction with dopamine D2 receptors by the metabotropic glutamate 2/3 receptor agonists 1S,2S,5R,6S-2-aminobicyclo[3.1.0]hexane-2,6-bicaroxylate monohydrate (LY354740) and (-)-2-oxa-4-aminobicyclo[3.1.0] Hexa

    Fell MJ et al (2009) J Pharmacol Exp Ther 331(3) : 1126-36.
  • Potential anti-anxiety, anti-addictive effects of LY 354740, a selective group II glutamate metabotropic receptors agonist in animal models.

    Kłodzińska A et al (1999) Neuropharmacology 38(12) : 1831-9.
  • Anxiolytic and side-effect profile of LY354740: a potent, highly selective, orally active agonist for group II metabotropic glutamate receptors.

    Helton DR et al (1998) J Pharmacol Exp Ther 284(2) : 651-60.
  • LY354740 is a potent and highly selective group II metabotropic glutamate receptor agonist in cells expressing human glutamate receptors.

    Schoepp DD et al (1997) Neuropharmacology 36(1) : 1-11.

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