Mineralocorticoid

Selective mineralcorticoid receptor antagonist

Estrogen receptor (ER) antagonist and high affinity GPER agonist

Non-selective 5-HT₂ receptor antagonist. Shows activity at other receptors.

Potent glucocorticoid and progesterone receptor antagonist. Also used for gene editing as a mifepristone inducible Cas9 and Cpf1 CRISPR effector.

5-HT₄ receptor agonist. Also 5-HT₃ antagonist.

Selective ERα estrogen receptor antagonist

Selective ERβ estrogen receptor antagonist

Potent 5-HT₆ antagonist

Mineralocorticoid and androgen receptor antagonist

Estrogen receptor antagonist/ partial agonist. May be used in genome engineering (e.g. CreER/ CRISPR-Cas9).