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Eplerenone

(HB2527)
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Product overview

Name Eplerenone
Alternative names Inspra, Epoxymexrenone
Purity >99%
Description Selective mineralcorticoid receptor antagonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description Selective mineralcorticoid receptor antagonist (IC50 = 990 nM). Shows little to no effect at androgen, estrogen or progesterone receptors. Shows cardioprotective and anti-apoptotic effects.

Solubility & Handling

Storage instructions Room temperature
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name

(7α,11α,17α)-9,11-Epoxy-17-hydroxy-3-o xo-pregn-4-ene-7,21-dicarboxylic acid γ-lactone methyl ester

Molecular Weight 414.5
Chemical structure Eplerenone Chemical Structure
Molecular Formula C24H30O6
CAS Number 107724-20-9
PubChem identifier 443872
SMILES O=C1CC[C@@]2(C)C(C[C@@H]([C@](OC)=O)[C@]3([H])[C@@](O6)2[C@H]6C[C@@]4(C)[C@]([H])3CC[C@@]54OC(CC5)=O)=C1
InChiKey JUKPWJGBANNWMW-VWBFHTRKSA-N

References for Eplerenone

References are publications that support the biological activity of the product

  • Eplerenone attenuated cardiac steatosis, apoptosis and diastolic dysfunction in experimental type-II diabetes.

    Ramã?rez E et al (2013) Cardiovasc Diabetol 12 : 172
    Read more (PubMedID: 24261558)

  • A new mode of mineralocorticoid receptor antagonism by a potent and selective nonsteroidal molecule.

    Fagart J et al (2010) J Biol Chem 285(39) : 29932-40.
    Read more (PubMedID: 20650892)

  • Recent studies with eplerenone, a novel selective aldosterone receptor antagonist.

    McMahon EG (2001) Curr Opin Pharmacol 1(2) : 190-6.
    Read more (PubMedID: 11714095)

3 Item(s)

Grouped product items
Order: HB2527
Pack PriceQty
10mg
$121
50mg
$524
Selective mineralcorticoid receptor antagonist
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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