Product overview

Name Eplerenone
Description Selective mineralcorticoid receptor antagonist
Alternative names Inspra, Epoxymexrenone
Purity >99%
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Biological Data

Biological description Selective mineralcorticoid receptor antagonist (IC50 = 990 nM). Shows little to no effect at androgen, estrogen or progesterone receptors. Shows cardioprotective and anti-apoptotic effects.

Solubility & Handling

Storage instructions Room temperature
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name (7α,11α,17α)-9,11-Epoxy-17-hydroxy-3-o xo-pregn-4-ene-7,21-dicarboxylic acid γ-lactone methyl ester
Molecular Weight 414.5
Chemical structure Eplerenone Chemical Structure
Molecular Formula C24H30O6
CAS Number 107724-20-9
PubChem identifier 443872
SMILES O=C1CC[C@@]2(C)C(C[C@@H]([C@](OC)=O)[C@]3([H])[C@@](O6)2[C@H]6C[C@@]4(C)[C@]([H])3CC[C@@]54OC(CC5)=O)=C1
InChiKey JUKPWJGBANNWMW-VWBFHTRKSA-N

References for Eplerenone

References are publications that support the biological activity of the product
  • Eplerenone attenuated cardiac steatosis, apoptosis and diastolic dysfunction in experimental type-II diabetes.

    Ramã?rez E et al (2013) Cardiovasc Diabetol 12 : 172
  • A new mode of mineralocorticoid receptor antagonism by a potent and selective nonsteroidal molecule.

    Fagart J et al (2010) J Biol Chem 285(39) : 29932-40.
  • Recent studies with eplerenone, a novel selective aldosterone receptor antagonist.

    McMahon EG (2001) Curr Opin Pharmacol 1(2) : 190-6.