Group I (mGlu5, mGlu1)
Group I metabotropic glutamate receptors (mGlu1, mGlu5) are coupled with phospholipase C (PLC) via Gq proteins; activation causes increased levels of IP3 and diacylglycerol, with intracellullar Ca2+ release and protein kinase C (PKC) activation. Group I receptors are predominantly located post synaptically. Researchers can save 50% on group I metabotropic glutamate receptor agonists, antagonists, positive allosteric modulators (PAMs) and negative allosteric modulators (NAMs) from Hello Bio - they are up to half the price of other suppliers.
(S)-4-Carboxyphenylglycine (HB0049)
Description:Competitive, selective group 1 mGlu antagonist
Purity:>99%
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(S)-3,5-DHPG (HB0045)
Description:Selective group I mGlu receptor agonist. Induces LTD.
Purity:>99%
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LY-367385 hydrochloride (HB5153)
Description:Potent, highly selective mGlu1a antagonist. Water soluble.
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MTEP hydrochloride (HB0431)
Description:Potent, highly selective, non-competitive mGluR5 antagonist
Purity:>98%
