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CPCCOEt

(HB0216)
Publications (1)
Technical documents: SDS CoA Datasheet
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Product overview

Name CPCCOEt
Purity >99%
Description Selective, non-competitive mGlu1 antagonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (3) Reviews Publications (1) References (3) Frequently bought together
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CPCCOEt product vial image | Hello Bio
CPCCOEt product vial image | Hello Bio

CPCCOEt product vial image | Hello Bio

CPCCOEt product vial image | Hello Bio

Biological Data

Biological description Selective and non-competitive mGlu1 receptor antagonist (IC50 = 6.5 µM). Displays no agonist or antagonist activity at mGlu2, 4a, 5a, 7b and 8a or iGlu receptors at concentrations up to 100µM. Prevents rebound potentiation.

Solubility & Handling

Solubility overview Soluble in DMSO (100mM)
Storage instructions Room temperature
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name 7-(Hydroxyimino)cyclopropa[b]chromen-1a-carboxylate ethyl ester
Molecular Weight 247.25
Chemical structure CPCCOEt [179067-99-3] Chemical Structure
Molecular Formula C13H13NO4
CAS Number 179067-99-3
PubChem identifier 6278000
SMILES CCOC(=O)C12CC1/C(=N\O)/C3=CC=CC=C3O2
Source Synthetic
InChi InChI=1S/C13H13NO4/c1-2-17-12(15)13-7-9(13)11(14-16)8-5-3-4-6-10(8)18-13/h3-6,9,16H,2,7H2,1H3/b14-11-
InChiKey FXCTZFMSAHZQTR-KAMYIIQDSA-N
MDL number MFCD00947859
Appearance White solid

References for CPCCOEt

References are publications that support the biological activity of the product

  • mGluR1-mediated facilitation of long-term potentiation at inhibitory synapses on a cerebellar Purkinje neuron.

    Sugiyama Y et al (2008) Eur J Neurosci 27(4) : 884-96.
    Read more (PubMedID: 18279362)

  • CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding.

    Litschig S et al (1999) Mol Pharmacol 55(3) : 453-61.
    Read more (PubMedID: 10051528)

  • Reversible and non-competitive antagonist profile of CPCCOEt at the human type 1alpha metabotropic glutamate receptor.

    Hermans E et al (1998) Neuropharmacology 37(12) : 1645-7.
    Read more (PubMedID: 9886688)

3 Item(s)

Publications
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These publications cite the use of CPCCOEt purchased from Hello Bio:

  • Phenotypic characterization of Grm1crv4 mice reveals a functional role for the type 1 metabotropic glutamate receptor in bone mineralization.

    Musante et al (2017) Bone. 94 : 114-123
    PubMedID: 27989650

1 Item

Related Products
Grouped product items
Order: HB0216
Pack PriceQty
10mg
$133
50mg
$514
Selective, non-competitive mGlu1 antagonist
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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