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Images CPCCOEt product vial image | Hello Bio
CPCCOEt product vial image | Hello Bio Biological Data Biological description Selective and non-competitive mGlu1 receptor antagonist (IC50 = 6.5 µM). Displays no agonist or antagonist activity at mGlu2, 4a, 5a, 7b and 8a or iGlu receptors at concentrations up to 100µM. Prevents rebound potentiation.
Solubility & Handling Storage instructions Room temperature
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 7-(Hydroxyimino)cyclopropa[b ]chromen-1a-carboxylate ethyl ester
Chemical structure
Molecular Formula C13 H13 NO4
PubChem identifier 6278000
SMILES CCOC(=O)C12CC1/C(=N\O)/C3=CC=CC=C3O2
InChi InChI=1S/C13H13NO4/c1-2-17-12(15)13-7-9(13)11(14-16)8-5-3-4-6-10(8)18-13/h3-6,9,16H,2,7H2,1H3/b14-11-
InChiKey FXCTZFMSAHZQTR-KAMYIIQDSA-N
References for CPCCOEt References are publications that support the biological activity of the product
mGluR1-mediated facilitation of long-term potentiation at inhibitory synapses on a cerebellar Purkinje neuron. Sugiyama Y et al (2008) Eur J Neurosci 27(4) : 884-96. CPCCOEt, a noncompetitive metabotropic glutamate receptor 1 antagonist, inhibits receptor signaling without affecting glutamate binding. Litschig S et al (1999) Mol Pharmacol 55(3) : 453-61. Reversible and non-competitive antagonist profile of CPCCOEt at the human type 1alpha metabotropic glutamate receptor. Hermans E et al (1998) Neuropharmacology 37(12) : 1645-7.
Publications
These publications cite the use of CPCCOEt purchased from Hello Bio:
Phenotypic characterization of Grm1crv4 mice reveals a functional role for the type 1 metabotropic glutamate receptor in bone mineralization. Musante et al (2017) Bone. 94 : 114-123
Selective, non-competitive mGlu1 antagonist
![CPCCOEt [179067-99-3] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0216.png "CPCCOEt [179067-99-3]")
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