Target

Effective agonist for muscarinic-based DREADDs in vitro and in vivo. Non-CNO chemogenetic actuator. Brain penetrant.

Potent 5-HT and NA reuptake inhibitor. Also inhibits dopamine reuptake.

Cell-permeable, non-competitive dynamin inhibitor

Potent, selective K_v11.1 channel blocker

Group I / II mGlu antagonist

Potent, selective CaM antagonist

Epithelial K_Ca channel activator. Promotes ESC differentiation into cardiomyocytes.

Broad enzyme inhibitor. Inhibits Gq protein signaling.

Synthetic retinoid. Induces neural differentiation of hESCs.

Potent and selective FXR agonist