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Biological Data Biological description Group I / II mGluR antagonist. Shows neuroprotective actions against glucocorticoid-mediated apoptosis.
Solubility & Handling Storage instructions Room temperature
Solubility overview Soluble in NaOH(aq) (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
Chemical Data Chemical name (RS )-α-Ethyl-4-carboxyphenylglycine
Chemical structure
Molecular Formula C11 H13 NO4
PubChem identifier 3937355
SMILES NC(C(O)=O)(CC)C1=CC=C(C(O)=O)C=C1
InChi InChI=1S/C11H13NO4/c1-2-11(12,10(15)16)8-5-3-7(4-6-8)9(13)14/h3-6H,2,12H2,1H3,(H,13,14)(H,15,16)
InChiKey AIEFWRHRHFRLFT-UHFFFAOYSA-N
References for E4CPG References are publications that support the biological activity of the product
Ionotropic and metabotropic glutamate receptor mediation of glucocorticoid-induced apoptosis in hippocampal cells and the neuroprotective role of synaptic N-methyl-D-aspartate receptors. Lu J et al (2003) Neuroscience 121(1) : 123-31. Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Sekiyama N et al (1996) Br J Pharmacol 117(7) : 1493-503. Structure-activity relationships for a series of phenylglycine derivatives acting at metabotropic glutamate receptors (mGluRs). Bedingfield JS et al (1995) Br J Pharmacol 116(8) : 3323-9.
Group I / II mGlu antagonist
![E4CPG [170846-89-6] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0268.png "E4CPG [170846-89-6]")
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