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Biological Data

Biological description Group I / II mGluR antagonist. Shows neuroprotective actions against glucocorticoid-mediated apoptosis.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in NaOH(aq) (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

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Dilution

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Chemical Data

Purity >98%
Chemical name (RS)-α-Ethyl-4-carboxyphenylglycine
Molecular Weight 223.23
Chemical structure E4CPG  [170846-89-6] Chemical Structure
Molecular Formula C11H13NO4
CAS Number 170846-89-6
PubChem identifier 3937355
SMILES NC(C(O)=O)(CC)C1=CC=C(C(O)=O)C=C1
InChi InChI=1S/C11H13NO4/c1-2-11(12,10(15)16)8-5-3-7(4-6-8)9(13)14/h3-6H,2,12H2,1H3,(H,13,14)(H,15,16)
InChiKey AIEFWRHRHFRLFT-UHFFFAOYSA-N
MDL number MFCD01074798

References for E4CPG

References are publications that support the biological activity of the product
  • Ionotropic and metabotropic glutamate receptor mediation of glucocorticoid-induced apoptosis in hippocampal cells and the neuroprotective role of synaptic N-methyl-D-aspartate receptors.

    Lu J et al (2003) Neuroscience 121(1) : 123-31.
  • Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes.

    Sekiyama N et al (1996) Br J Pharmacol 117(7) : 1493-503.
  • Structure-activity relationships for a series of phenylglycine derivatives acting at metabotropic glutamate receptors (mGluRs).

    Bedingfield JS et al (1995) Br J Pharmacol 116(8) : 3323-9.

3 Item(s)