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Biological Data

Biological description DPCPX is a potent and selective A1 adenosine receptor inverse agonist (Ki values are 0.45 and 300 nM at A1 and A2 receptors respectively). Active in vivo.

DPCPX facilitates long term potentiation (LTP) and blocks induction of long term depression (LTD).

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (5 mM) and in ethanol (10 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name 8-Cyclopentyl-1,3-dipropylxanthine
Molecular Weight 304.39
Chemical structure DPCPX [102146-07-6] Chemical Structure
Molecular Formula C16H24N4O2
CAS Number 102146-07-6
PubChem identifier 1329
Source Synthetic
InChi InChI=1S/C16H24N4O2/c1-3-9-19-14-12(15(21)20(10-4-2)16(19)22)17-13(18-14)11-7-5-6-8-11/h11H,3-10H2,1-2H3,(H,17,18)
MDL number MFCD00055117
Appearance White solid

References for DPCPX

References are publications that support the biological activity of the product
  • Caffeine, adenosine receptors, and synaptic plasticity.

    Costenla et al (2010) J Alzheimers Dis 1 : S25-34
  • ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor.

    Li et al (2007) J Pharmacol Exp Ther. 320(2) : 637-45
  • Activation of receptors negatively coupled to adenylate cyclase is required for induction of long-term synaptic depression at Schaffer collateral-CA1 synapses.

    Santschi et al (2006) J Neurobiol 66(3) : 205-19
  • Effects of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), a highly selective adenosine receptor antagonist, on force of contraction in guinea-pig atrial and ventricular cardiac preparations.

    von der Leyen et al (1989) Naunyn Schmiedebergs Arch Pharmacol. 340(2) : 204-9
  • 8-Cyclopentyl-1,3-dipropylxanthine (DPCPX)--a selective high affinity antagonist radioligand for A1 adenosine receptors.

    Lohse et al (1987) Naunyn Schmiedebergs Arch Pharmacol. 336(2) : 204-10

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