DPCPX is a potent and selective A1 adenosine receptor inverse agonist (Ki values are 0.45 and 300 nM at A1 and A2 receptors respectively). Active in vivo.
DPCPX facilitates long term potentiation (LTP) and blocks induction of long term depression (LTD).
Solubility & Handling
Storage instructions
Room temperature
Solubility overview
Soluble in DMSO (5 mM) and in ethanol (10 mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor.
Li et al (2007) J Pharmacol Exp Ther. 320(2) : 637-45
Activation of receptors negatively coupled to adenylate cyclase is required for induction of long-term synaptic depression at Schaffer collateral-CA1 synapses.
Effects of 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), a highly selective adenosine receptor antagonist, on force of contraction in guinea-pig atrial and ventricular cardiac preparations.
von der Leyen et al (1989) Naunyn Schmiedebergs Arch Pharmacol. 340(2) : 204-9
![DPCPX [102146-07-6] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb2094_2.png "DPCPX [102146-07-6]")
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