Microtubule

Piezo1 channel activator

Potently induces chondrogenesis in MSCs

Novel, selective Piezo1 channel activator. Improved efficacy and potency compared to Yoda1.

K_ir6 channel activator

LKB1/AMPK activator. Also promotes neurogenesis.

mTOR activator and autophagy inhibitor. Cell-permeable.

K_ir6 channel activator

Selective K_v7.2 / K_v7.4 channel activator

Selective K_2P2.1 (TREK-1) and K_2P10.1 (TREK-2) activator

Covalent K_2P2.1 (TREK-1) modulator. Used with CAT335 as part of the CATKLAMP chemogenetic strategy.