Selective Kv7.2 and Kv7.4 channel activator (EC50 values are 230 and 510 nM respectively). Exhibits >80-fold selectivity for Kv7.2 and Kv7.4 channels over other K+ channels. Displays vasorelaxant properties.
Solubility & Handling
Solubility overview
Soluble in DMSO (50mM) or ethanol (50mM)
Storage instructions
+4°C
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Discovery, Synthesis, and Structure Activity Relationship of a Series of N-Aryl- bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener.
Yu H et al (2011) ACS Chem Neurosci 2(10) : 572-577.
![ML 213 [489402-47-3] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1064.png "ML 213 [489402-47-3]")
Understanding purity and quality - a guide for life scientists