ML 336 (K2P2.1/ TREK-1 modulator)

Technical documents: Datasheet

Product overview

Name ML 336 (K2P2.1/ TREK-1 modulator)
Description Covalent K2P2.1 (TREK-1) modulator
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Biological Data

Biological description K2P2.1 (TREK-1) modulator. Recently used with CAT335 as part of the CATKLAMP chemogenetic strategy which uses the pair of compounds to rapidly and irreversiblly activate engineered TREK subfamily members which will allow further probing of K2P function and act as a switch to silence neuronal firing. When used with ML336, selectively and covalently activates engineered versions of different K2P TREK subfamily members e.g. K2P2.1 (TREK-1), K2P10.1 (TREK-2), K2P4.1(TRAAK).

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Chemical name N-[(2,4-dichlorophenyl)methyl]-4-(prop-2-enamido)benzamide
Molecular Weight 349.2
Chemical structure  Chemical Structure
Molecular Formula C17H14Cl2N2O2
CAS Number 1629267-48-6
SMILES Clc1cc(Cl)ccc1CNC(=O)c1ccc(NC(=O)C=C)cc1
Source Synthetic
InChi InChI=1S/C17H14Cl2N2O2/c1-2-16(22)21-14-7-4-11(5-8-14)17(23)20-10-12-3-6-13(18)9-15(12)19/h2-9H,1,10H2,(H,20,23)(H,21,22)

References for ML 336 (K2P2.1/ TREK-1 modulator)

References are publications that support the biological activity of the product
  • Development of covalent chemogenetic K(2P) channel activators.

    Deal PE et al (2023) bioRxiv : the preprint server for biology :

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