ML 336 (K2P2.1/ TREK-1 modulator)

K_2P2.1 (TREK-1) modulator. Recently used with CAT335 as part of the CATKLAMP chemogenetic strategy which uses the pair of compounds to rapidly and irreversiblly activate engineered TREK subfamily members to allow further probing of K_2P function and act as a switch to silence neuronal firing. Selectively and covalently activates engineered versions of different K_2P TREK subfamily members when used with CAT335, e.g. K_2P2.1 (TREK-1), K_2P10.1 (TREK-2), K_2P4.1(TRAAK).