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ML 335

(HB6763)
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Product overview

Name ML 335
Alternative names ML-335, ML335, ML 335
Purity >98%
Description Selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (5)
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Biological Data

Biological description Selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator (EC50 values are 14.3µM and 5.2 µM respectively) that does not activate K2P4.1 (TRAAK).

Solubility & Handling

Solubility overview Soluble in DMSO (100 mM), and in ethanol (20 mM)
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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More Info

Dilution

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Chemical Data

Purity >98%
Chemical name N-[(2,4-Dichlorophenyl)methyl]-4-[(methylsulfonyl)amino]benzamide
Molecular Weight 373.25
Chemical structure Chemical Structure
Molecular Formula C15H14Cl2N2O3S
CAS Number 825658-06-8
PubChem identifier 1243054
SMILES CS(=O)(=O)NC1=CC=C(C=C1)C(=O)NCC2=C(C=C(C=C2)Cl)Cl
InChi InChI=1S/C15H14Cl2N2O3S/c1-23(21,22)19-13-6-3-10(4-7-13)15(20)18-9-11-2-5-12(16)8-14(11)17/h2-8,19H,9H2,1H3,(H,18,20)
InChiKey RDFIQTZRJRVFHK-UHFFFAOYSA-N
MDL number MFCD12985402

References for ML 335

References are publications that support the biological activity of the product

  • The TREK-1 potassium channel is a potential pharmacological target for vasorelaxation in pulmonary hypertension.

    Csáki R et al (2024) British journal of pharmacology :
    Read more (PubMedID: 38807478)

  • K(2P) channel C-type gating involves asymmetric selectivity filter order-disorder transitions.

    Lolicato M et al (2020) Science advances 6 :
    Read more (PubMedID: 33127683)

  • Protein and Chemical Determinants of BL-1249 Action and Selectivity for K(2P) Channels.

    Pope L et al (2018) ACS chemical neuroscience 9 : 3153-3165
    Read more (PubMedID: 30089357)

  • TREK-1 channels regulate pressure sensitivity and calcium signaling in trabecular meshwork cells.

    Yarishkin O et al (2018) The Journal of general physiology 150 : 1660-1675
    Read more (PubMedID: 30446509)

  • K(2P)2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site.

    Lolicato M et al (2017) Nature 547 : 364-368
    Read more (PubMedID: 28693035)

5 Item(s)

Related Products
Grouped product items
Order: HB6763
Pack PriceQty
10mg
$85
50mg
$352
Selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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Fax 609-228-4994

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