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Biological Data
| Biological description | Selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator (EC50 values are 14.3µM and 5.2 µM respectively) that does not activate K2P4.1 (TRAAK). |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (100 mM), and in ethanol (20 mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | N-[(2,4-Dichlorophenyl)methyl]-4-[(methylsulfonyl)amino]benzamide |
| Chemical structure |  |
| Molecular Formula | C15H14Cl2N2O3S |
| PubChem identifier | 1243054 |
| SMILES | CS(=O)(=O)NC1=CC=C(C=C1)C(=O)NCC2=C(C=C(C=C2)Cl)Cl |
| InChi | InChI=1S/C15H14Cl2N2O3S/c1-23(21,22)19-13-6-3-10(4-7-13)15(20)18-9-11-2-5-12(16)8-14(11)17/h2-8,19H,9H2,1H3,(H,18,20) |
| InChiKey | RDFIQTZRJRVFHK-UHFFFAOYSA-N |
References for ML 335
References are publications that support the biological activity of the product
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The TREK-1 potassium channel is a potential pharmacological target for vasorelaxation in pulmonary hypertension.
Csáki R et al (2024) British journal of pharmacology : -
K(2P) channel C-type gating involves asymmetric selectivity filter order-disorder transitions.
Lolicato M et al (2020) Science advances 6 : -
Protein and Chemical Determinants of BL-1249 Action and Selectivity for K(2P) Channels.
Pope L et al (2018) ACS chemical neuroscience 9 : 3153-3165 -
TREK-1 channels regulate pressure sensitivity and calcium signaling in trabecular meshwork cells.
Yarishkin O et al (2018) The Journal of general physiology 150 : 1660-1675 -
K(2P)2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site.
Lolicato M et al (2017) Nature 547 : 364-368
Selective K2P2.1 (TREK-1) and K2P10.1 (TREK-2) activator
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