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Biological Data Biological description Selective K2P 2.1 (TREK-1) and K2P 10.1 (TREK-2) activator (EC50 values are 14.3µM and 5.2 µM respectively) that does not activate K2P 4.1 (TRAAK).
Solubility & Handling Storage instructions +4°C
Solubility overview Soluble in DMSO (100 mM), and in ethanol (20 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name N-[(2,4-Dichlorophenyl)methyl]-4-[(methylsulfonyl)amino]benzamide
Chemical structure
Molecular Formula C15 H14 Cl2 N2 O3 S
PubChem identifier 1243054
SMILES CS(=O)(=O)NC1=CC=C(C=C1)C(=O)NCC2=C(C=C(C=C2)Cl)Cl
InChi InChI=1S/C15H14Cl2N2O3S/c1-23(21,22)19-13-6-3-10(4-7-13)15(20)18-9-11-2-5-12(16)8-14(11)17/h2-8,19H,9H2,1H3,(H,18,20)
InChiKey RDFIQTZRJRVFHK-UHFFFAOYSA-N
References for ML 335 References are publications that support the biological activity of the product
The TREK-1 potassium channel is a potential pharmacological target for vasorelaxation in pulmonary hypertension. Csáki R et al (2024) British journal of pharmacology : K(2P) channel C-type gating involves asymmetric selectivity filter order-disorder transitions. Lolicato M et al (2020) Science advances 6 : Protein and Chemical Determinants of BL-1249 Action and Selectivity for K(2P) Channels. Pope L et al (2018) ACS chemical neuroscience 9 : 3153-3165 TREK-1 channels regulate pressure sensitivity and calcium signaling in trabecular meshwork cells. Yarishkin O et al (2018) The Journal of general physiology 150 : 1660-1675 K(2P)2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site. Lolicato M et al (2017) Nature 547 : 364-368
Selective K2P 2.1 (TREK-1) and K2P 10.1 (TREK-2) activator
Understanding purity and quality - a guide for life scientists
