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Levcromakalim

(HB1093)
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Product overview

Name Levcromakalim
Alternative names BRL 38227
Purity >99%
Description Kir6 channel activator
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description Cromakalim active enantiomer. Kir6 (KATP) channel activator. Induces a glibenclamide-sensitive, non-inactivating K-current (IKCO) in smooth muscle and inhibits the slow delayed rectifier K-current (ITO). Lowers cholesterol and triglyceride in diabetes, but inhibits insulin. Shows vasodilator actions.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name (3S,4R)-3,4-dihydro-3-hydroxy-2,2-d imethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6 -carbonitrile
Molecular Weight 286.33
Chemical structure Levcromakalim [94535-50-9] Chemical Structure
Molecular Formula C16H18N2O3
CAS Number 94535-50-9
PubChem identifier 93504
SMILES O=C1CCCN1[C@H]2[C@H](O)C(C)(C)OC3=C2C=C(C#N)C=C3
InChiKey TVZCRIROJQEVOT-CABCVRRESA-N

References for Levcromakalim

References are publications that support the biological activity of the product

  • Evaluation of the potassium channel activator levcromakalim (BRL38227) on the lipid profile, electrolytes and blood glucose levels of streptozotocin-diabetic rats.

    Owolabi OJ et al (2013) J Diabetes 5(1) : 88-94.
    Read more (PubMedID: 23374501)

  • [Effect of levcromakalim and cromakalim on ATP-sensitive K+ channel of pulmonary arterial smooth muscle cells in pulmonary hypertensive rats].

    Xiao XR et al (2003) Zhonghua Jie He He Hu Xi Za Zhi 26(2) : 97-100.
    Read more (PubMedID: 12783661)

  • Potassium channel modulation in rat portal vein by ATP depletion: a comparison with the effects of levcromakalim (BRL 38227).

    Noack T et al (1992) Br J Pharmacol 107(4) : 945-55.
    Read more (PubMedID: 1467843)

3 Item(s)

Grouped product items
Order: HB1093
Pack PriceQty
10mg
$245
50mg
$1,006
Kir6 channel activator
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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