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MHY 1485

(HB7154)
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Technical documents: Datasheet

Product overview

Name MHY 1485
Alternative names MHY1485
Purity >98%
Description mTOR activator and autophagy inhibitor. Cell-permeable.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description mTOR activator and autophagy inhibitor. Cell permeable. Markedly increases the LC3II/LC3I ratio in a dose- and time- dependent manner by inhibition of the fusion between autophagosomes and lysosomes, and without increasing the autophagic flux. Less toxic than other autophagy inhibitors.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (50 mM with gentle warming)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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More Info

Dilution

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More Info

Chemical Data

Purity >98%
Chemical name 4,6-Bis(morpholin-4-yl)-N-(4-nitrophenyl)-1,3,5-triazin-2-amine
Molecular Weight 387.39
Chemical structure 326914-06-1 [MHY 1485] Chemical Structure
Molecular Formula C17H21N7O4
CAS Number 326914-06-1
PubChem identifier 2834965
SMILES [O-][N+](=O)c1ccc(cc1)Nc1nc(nc(n1)N1CCOCC1)N1CCOCC1
InChi InChI=1S/C17H21N7O4/c25-24(26)14-3-1-13(2-4-14)18-15-19-16(22-5-9-27-10-6-22)21-17(20-15)23-7-11-28-12-8-23/h1-4H,5-12H2,(H,18,19,20,21)
InChiKey MSSXBKQZZINCRI-UHFFFAOYSA-N
MDL number MFCD00489974

References for MHY 1485

References are publications that support the biological activity of the product

  • MHY1485 enhances X-irradiation-induced apoptosis and senescence in tumor cells.

    Sun L et al (2021) Journal of radiation research 62 : 782-792
    Read more (PubMedID: 34265852)

  • MHY1485 activates mTOR and protects osteoblasts from dexamethasone.

    Zhao S et al (2016) Biochemical and biophysical research communications 481 : 212-218
    Read more (PubMedID: 27884298)

  • Inhibitory effect of mTOR activator MHY1485 on autophagy: suppression of lysosomal fusion.

    Choi YJ et al (2012) PloS one 7 : e43418
    Read more (PubMedID: 22927967)

3 Item(s)

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Grouped product items
Order: HB7154
Pack PriceQty
10mg
$58
50mg
$182
mTOR activator and autophagy inhibitor. Cell-permeable.
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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