Product overview
Name | NMDA |
Description | Prototypic NMDA receptor agonist |
Purity | >99% |
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Biological Data
Biological description | Prototypic NMDA receptor agonist which mimics the action of glutamate. Potent excitant. |
Application notes | The prototypic NMDA receptor agonist NMDA is effective at a range of concentrations and typically used at 100 μM. NMDA from Hello Bio induces inward depolarising whole-cell currents in cortical neurons at 10 μM with prominent currents at 50 μM. The actions of NDMA were fully blocked by D-AP5 (NMDAR antagonist) at 100 μM (see Fig 1 above).
#Protocol 1: NMDA mediated whole-cell currents
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Solubility & Handling
Storage instructions | Room temperature |
Solubility overview | Soluble in water (100mM) |
Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
Purity | >99% |
Chemical name | N-Methyl-D-aspartic acid |
Molecular Weight | 147.13 |
Chemical structure | |
Molecular Formula | C5H9NO4 |
CAS Number | 6384-92-5 |
PubChem identifier | 22880 |
SMILES | CN[C@H](CC(=O)O)C(=O)O |
InChi | InChI=1S/C5H9NO4/c1-6-3(5(9)10)2-4(7)8/h3,6H,2H2,1H3,(H,7,8)(H,9,10)/t3-/m1/s1 |
InChiKey | HOKKHZGPKSLGJE-GSVOUGTGSA-N |
MDL number | MFCD00004226 |
References for NMDA
References are publications that support the biological activity of the product
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Regulation of N-methyl-D-aspartic acid (NMDA) receptors by metabotropic glutamate receptor 7.
Gu Z et al (2012) J Biol Chem 287(13) : 10265-75. -
N-methyl-D-aspartic acid (NMDA) in the nervous system of the amphioxus Branchiostoma lanceolatum.
D'Aniello S et al (2007) BMC Neurosci 8 : 109 -
Occurrence of D-aspartic acid and N-methyl-D-aspartic acid in rat neuroendocrine tissues and their role in the modulation of luteinizing hormone and growth hormone release.
D'Aniello A et al (2000) FASEB J 14(5) : 699-714.
Publications
These publications cite the use of NMDA purchased from Hello Bio:
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Dendritic autophagy degrades postsynaptic proteins and is required for long-term synaptic depression in mice
Kallergi E et al (2022) Nat Commun 13(1) : 680PubMedID: 35115539 -
Signaling pathways involved in NMDA-induced suppression of M-channels in corticotropin-releasing hormone neurons in central amygdala
Zhang H et al (2022) J Neurochem 161(6) : 478-491PubMedID: 35583089 -
Specific pathogenic mutations in the M3 domain of the GluN1 subunit regulate the surface delivery and pharmacological sensitivity of NMDA receptors
Kolcheva M et al (2021) Neuropharmacology 189 : 108528PubMedID: 33773999 -
Excitotoxicity and NMDA receptor-mediated acquired neuroprotection in human iPSC-derived brain organoids
Bauersachs et al (2021) 10.11588/heidok.00030808 -
Long-term synaptic depression triggers local biogenesis of autophagic vesicles in dendrites and requires autophagic degradation
Kallergi et al. (2020) bioRxiv preprint : 1-46