Product overview
Name | CNQX disodium salt |
Description | Potent, competitive AMPA / kainate receptor antagonist. Disodium salt. |
Purity | >98% |
Customer comments | The CNQX is going fine ! Verified customer, IBPS, Inserm, CNRS It works exactly as it should! Dissolved in water, kept in aliquots in -20 freezer. Verified customers, SickKids (University of Toronto) |
Images
Biological Data
Biological description | CNQX disodium salt is a water soluble, potent and competitive AMPA and kainate receptor antagonist. CNQX also antagonizes NMDA receptors at the glycine site.
|
Application notes | The AMPA receptor antagonist CNQX disodium salt is commonly used at concentrations of 10 μM to inhibit the actions of glutamate acting on AMPARs. CNQX disodium salt from Hello Bio reduces both spontaneous and evoked EPSCs in cortical neurons at concentrations of 1 μM with full AMPA receptor blockade at 10 μM (see Fig 1 above).
#Protocol 1: Evoked and spontaneous excitatory post synaptic currents (EPSCs)
|
Solubility & Handling
Storage instructions | Room temperature (desiccate) |
Solubility overview | Soluble in water (20mM) |
Handling | Hydroscopic solid, contact with air may cause material to change colour and become sticky. Product performance should not be affected but we recommend storing the material in a sealed jar. |
Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
Chemical name | 6-Cyano-7-nitroquinoxaline-2,3-dione disodium |
Molecular Weight | 276.12 |
Chemical structure | |
Molecular Formula | C9H2N4O4Na2 |
CAS Number | 479347-85-8 |
PubChem identifier | 2821 |
SMILES | C1=C(C(=CC2=C1N=C(C(=N2)[O-])[O-])[N+](=O)[O-])C#N.[Na+].[Na+] |
Source | Synthetic |
InChi | InChI=1S/C9H4N4O4.2Na/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5;;/h1-2H,(H,11,14)(H,12,15);;/q;2*+1/p-2 |
InChiKey | YCXDDPGRZKUGDG-UHFFFAOYSA-L |
MDL number | MFCD09953908 |
Appearance | Brown or yellow solid |
References for CNQX disodium salt
-
The calpain inhibitor MDL-28170 and the AMPA/KA receptor antagonist CNQX inhibit neurofilament degradation and enhance neuronal survival in kainic acid-treated hippocampal slice cultures.
Lopez-Picon FR et al (2006) Eur J Neurosci 23(10) : 2686-94. -
6-Cyano-7-nitroquinoxaline-2,3-dione (CNQX) increases GABAA receptor-mediated spontaneous postsynaptic currents in the dentate granule cells of rat hippocampal slices.
Hashimoto Y et al (2004) Neurosci Lett 358(1) : 33-6. -
Pharmacological characterization of glutamatergic agonists and antagonists at recombinant human homomeric and heteromeric kainate receptors in vitro.
Alt et al (2004) Neuropharmacology 46(6) : 793-806 -
6,7-Dinitro-quinoxaline-2,3-dion and 6-nitro,7-cyano-quinoxaline-2,3-dion antagonise responses to NMDA in the rat spinal cord via an action at the strychnine-insensitive glycine receptor.
Birch PJ et al (1988) Eur J Pharmacol 156(1) : 177-80.
-
Downregulation of kainate receptors regulating GABAergic transmission in amygdala after early life stress is associated with anxiety-like behavior in rodents
Englund et al (2021) Transl Psychiatry. 538. : 11(1)PubMedID: 34663781 -
Different glutamate sources and endogenous co-agonists activate extrasynaptic NMDA receptors on amacrine cells of the rod pathway microcircuit
Beltran-Matas et al (2021) Eur J Neurosci. : 54(2)PubMedID: 34048091 -
Impaired cellular bioenergetics caused by GBA1 depletion sensitizes neurons to calcium overload
Plotegher et al. (2020) Cell Death Differ. 27(5) : 1588-1603PubMedID: 31685979 -
Probing the ionotropic activity of glutamate GluD2 receptor in HEK cells with genetically-engineered photopharmacology
Lemoine et al (2020) Elife 9: : e59026PubMedID: 33112237 -
Variance analysis as a tool to predict the mechanism underlying synaptic plasticity
van Huijstee AN et al (2020) J Neurosci Methods 331 : 108526PubMedID: 31756397