Product overview
| Name | (+)-MK 801 maleate |
| Alternative names | Dizocilpine maleate, Dizocilpine |
| Purity | >98% |
| Customer comments | We are using MK801 in our research. We are very satisfied with the quality of this product. Verified customer, UCSD (+)-MK 801 maleate does what it should! It is a very good product, delivered very rapidly. Verified customer, Research University Paris ...our first order with Hello Bio, has been satisfactory. The (+)-MK 801 Maleate has arrived in only some days and it was in perfect conditions. Verified customer, Universidad de La Laguna |
| Description | Potent, selective, non-competitive NMDA receptor antagonist |
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Images
Figure 1. (+)-MK 801 inhibition of evoked NMDAR mediated EPSCs in mouse cortical neuron
The NMDA receptor antagonist (+)-MK 801 is use-dependent and blocks NMDARs in their open conformation. (+)-MK 801 from Hello Bio fully abolishes evoked NMDAR currents at 10 µM rapidly upon repeated stimulations. At concentrations of 50 µM a more rapid receptor blockade was observed. For assay protocol, see #Protocol 1 in Application Notes below
Figure 2. (+)-MK 801 inhibition of evoked NMDAR mediated EPSCs in mouse cortical neuron
The NMDA receptor antagonist (+)-MK 801 is use-dependent and blocks NMDARs in their open conformation. (+)-MK 801 from Hello Bio fully abolishes evoked NMDAR currents at 10 µM rapidly upon repeated stimulations. At concentrations of 50 µM a more rapid receptor blockade was observed. For assay protocol, see #Protocol 1 in Application Notes below
(+)-MK 801 maleate: Scientist Approved
(+)-MK 801 maleate product vial image | Hello Bio
Figure 1. (+)-MK 801 inhibition of evoked NMDAR mediated EPSCs in mouse cortical neuron
The NMDA receptor antagonist (+)-MK 801 is use-dependent and blocks NMDARs in their open conformation. (+)-MK 801 from Hello Bio fully abolishes evoked NMDAR currents at 10 µM rapidly upon repeated stimulations. At concentrations of 50 µM a more rapid receptor blockade was observed. For assay protocol, see #Protocol 1 in Application Notes below
Figure 2. (+)-MK 801 inhibition of evoked NMDAR mediated EPSCs in mouse cortical neuron
The NMDA receptor antagonist (+)-MK 801 is use-dependent and blocks NMDARs in their open conformation. (+)-MK 801 from Hello Bio fully abolishes evoked NMDAR currents at 10 µM rapidly upon repeated stimulations. At concentrations of 50 µM a more rapid receptor blockade was observed. For assay protocol, see #Protocol 1 in Application Notes below
(+)-MK 801 maleate: Scientist Approved
(+)-MK 801 maleate product vial image | Hello Bio
Biological Data
| Biological description | Potent, selective and non-competitive NMDA receptor antagonist (Kd = 37.2 nM). Approx 10-fold more potent than (-)-MK 801 maleate. Prevents calcium ion influx and long term potentiation induction. Shows anticonvulsant and neuroprotective properties. |
| Application notes | The NMDA receptor antagonist (+)-MK 801 is use-dependent and blocks NMDARs in their open conformation. (+)-MK 801 from Hello Bio fully abolishes evoked NMDAR currents at 10 μM rapidly upon repeated stimulations (see Fig 1 above). At concentrations of 50 μM a more rapid receptor blockade was observed.
#Protocol 1: Evoked NMDA receptor currents
|
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in water (25mM, gentle warming) and in DMSO (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Purity | >98% |
| Chemical name | (5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate |
| Molecular Weight | 337.37 |
| Chemical structure | ![(+)-MK 801 maleate [77086-22-7] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0004.png "(+)-MK 801 maleate [77086-22-7]") |
| Molecular Formula | C16H15N.C4H4O4 |
| CAS Number | 77086-22-7 |
| PubChem identifier | 6420042 |
| SMILES | C[C@@]12C3=CC=CC=C3C[C@@H](N1)C4=CC=CC=C24.C(=C\C(=O)O)\C(=O)O |
| Source | Synthetic |
| InChi | InChI=1S/C16H15N.C4H4O4/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16;5-3(6)1-2-4(7)8/h2-9,15,17H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-,16+;/m1./s1 |
| InChiKey | QLTXKCWMEZIHBJ-PJGJYSAQSA-N |
| MDL number | MFCD00082465 |
| Appearance | White solid |
Technical guides
Understanding purity and quality - a guide for life scientistsReferences for (+)-MK 801 maleate
References are publications that support the biological activity of the product
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Effects of MK-801 stereoisomers on schedule-controlled behavior in rats.
Genovese RF et al (1991) Psychopharmacology (Berl) 105(4) : 477-80. -
The effects of dizocilpine maleate (MK-801), an antagonist of the N-methyl-D-aspartate receptor, on neurologic recovery and histopathology following complete cerebral ischemia in primates.
Lanier WL et al (1990) J Cereb Blood Flow Metab 10(2) : 252-61. -
MK-801 blocks NMDA receptor-mediated synaptic transmission and long term potentiation in rat hippocampal slices.
Coan EJ et al (1987) Neurosci Lett 80(1) : 111-4. -
The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.
Wong EH et al (1986) Proc Natl Acad Sci U S A 83(18) : 7104-8.
Publications
These publications cite the use of (+)-MK 801 maleate purchased from Hello Bio:
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Direct effects of radon exposure on the neural system-a possible target for pain relief
Joswig et al (2022) TUM : Thesis -
Functional independence of endogenous μ-and δ-opioid receptors co-expressed in cholinergic interneurons
Farrens et al (2021) bioRxiv https://doi.org/10.1101/2021.04.23.441175 : doi -
Synaptic mechanisms of top-down control by the auditory cortico-collicular pathway
Apostolides et al (2021) bioRxiv https://doi.org/10.1101/2021.07.26.453816 : doi -
Differential regulation of prelimbic and thalamic transmission to the basolateral amygdala by acetylcholine receptors
Mott et al (2021) bioRxiv https://doi.org/10.1101/2021.12.28.474396 : doi -
Shootin1a-mediated actin-adhesion coupling generates force to trigger structural plasticity of dendritic spines
Kastian RF et al (2021) Cell Rep 35(7) : 109130PubMedID: 34010643
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