L-Quisqualic acid
(HB0387)
Certificate of Analysis
Product overview
| Name | L-Quisqualic acid |
| Alternative names | QA, Quis, Quisqualate |
| Purity | >99% |
| Description | AMPA receptor agonist and group I mGlu agonist |
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Images
L-Quisqualic acid product vial image | Hello Bio
L-Quisqualic acid product vial image | Hello Bio
Biological Data
| Biological description | AMPA receptor agonist and group I mGlu agonist. Sensitizes hippocampal neurons to depolarization by excitatory amino acid analogues such as L-AP4, and L-AP6 ("the Quis effect"). Can also act as an excitotoxin and is used to lesion areas of the brain in rat models. |
Solubility & Handling
| Solubility overview | Soluble in NaOH(aq) (100mM, 1eq. NaOH) or water (10mM) |
| Storage instructions | Room temperature |
| Storage of solutions | Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use. |
| Shipping Conditions | Stable for ambient temperature shipping. Follow storage instructions on receipt. |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Purity | >99% |
| Chemical name | (L)-(+)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid |
| Molecular Weight | 189.13 |
| Chemical structure | ![L-Quisqualic acid [52809-07-1] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0387.png "L-Quisqualic acid [52809-07-1]") |
| Molecular Formula | C5H7N3O5 |
| CAS Number | 52809-07-01 |
| PubChem identifier | 40539 |
| SMILES | O=C1N(C[C@]([H])(N)C(O)=O)OC(N1)=O |
| InChi | InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1 |
| InChiKey | ASNFTDCKZKHJSW-REOHCLBHSA-N |
| MDL number | MFCD00069337 |
| Appearance | White solid |
Technical guides
Understanding purity and quality - a guide for life scientistsReferences for L-Quisqualic acid
References are publications that support the biological activity of the product
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Prolonged nociceptive responses to hind paw formalin injection in rats with a spinal cord injury.
Lee JW et al (2008) Neurosci Lett 439(2) : 212-5. -
L-Quisqualic acid transport into hippocampal neurons by a cystine-sensitive carrier is required for the induction of quisqualate sensitization.
Chase LA et al (2001) Neuroscience 106(2) : 287-301. -
C-fos expression in the rat nucleus basalis upon excitotoxic lesion with quisqualic acid: a study in adult and aged animals.
Giovannelli L et al (1998) J Neural Transm 105(8-9) : 935-48. -
Effects of quisqualic acid analogs on metabotropic glutamate receptors coupled to phosphoinositide hydrolysis in rat hippocampus.
Littman L et al (1995) Neuropharmacology 34(8) : 829-41.
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