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Biological Data
| Biological description | AMPA receptor positive allosteric modulator (PAM). Shows potential antipsychotic, neuroprotective actions, enhances cognitive function in rats and reverses opioid-induced respiratory depression. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (100mM) or ethanol (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | (2,3-Dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethanone |
| Molecular Formula | C14H17NO3 |
| SMILES | O=C(N3CCCCC3)C2=CC1=C(C=C2)OCCO1 |
| InChiKey | LJUNPHMOGNFFOS-UHFFFAOYSA-N |
References for CX 546
References are publications that support the biological activity of the product
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The ampakine CX546 restores the prepulse inhibition and latent inhibition deficits in mGluR5-deficient mice.
Lipina T et al (2007) Neuropsychopharmacology 32(4) : 745-56. -
Blockade of the metabotropic glutamate 2/3 receptors enhances social memory via the AMPA receptor in rats.
Shimazaki T et al (2007) Eur J Pharmacol 575(1-3) : 94-7. -
Ampakines alleviate respiratory depression in rats.
Ren J et al (2006) Am J Respir Crit Care Med 174(12) : 1384-91. -
Mechanism and impact of allosteric AMPA receptor modulation by the ampakine CX546.
Nagarajan N et al (2001) Neuropharmacology 41(6) : 650-63.
AMPA receptor positive allosteric modulator (PAM)
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