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CX 614

(HB1568)
Publications (1)
Technical documents: CoA Datasheet
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Product overview

Name CX 614
Alternative names BDP-37
Purity >99%
Description

AMPA receptor positive allosteric modulator (PAM)

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews Publications (1) References (2)
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Biological Data

Biological description

AMPA receptor positive allosteric modulator (PAM) that binds at an allosteric site (subsite A) only. Modulates channel deactivation and desensitization and shows antidepressant-like activity. Rapidly upregulates BDNF levels. Active in vivo.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM) or ethanol (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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More Info

Dilution

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Chemical Data

Purity >99%
Chemical name 2,3,6a,7,8,9-Hexahydro-11H-1,4-dioxino[2,3-g]pyrrolo[2,1-b][1,3]benzoxazin-11-one, 2H,3H,6aH-Pyrrolidino[2",1"-3′,2′]1,3-oxazino[6′,5′-5,4]benzo[e]1,4-dioxan-10-one
Molecular Weight 247.25
Chemical structure CX614 [191744-13-5] Chemical Structure
Molecular Formula

C13H13NO4

CAS Number 191744-13-5
PubChem identifier 6451148
SMILES O=C2N4C(CCC4)OC1=CC3=C(OCCO3)C=C12
Source Synthetic
InChiKey RQEPVMAYUINZRE-UHFFFAOYSA-N
Appearance white solid

References for CX 614

References are publications that support the biological activity of the product

  • Ampakine CX614 increases respiratory rate in a mouse model of Parkinson's disease.

    Oliveira LM et al (2023) Brain research 1815 : 148448
    Read more (PubMedID: 37301422)

  • Effects of the potent ampakine CX614 on hippocampal and recombinant AMPA receptors: interactions with cyclothiazide and GYKI 52466.

    Arai AC et al (2000) Molecular pharmacology 58 : 802-13
    Read more (PubMedID: 10999951)

2 Item(s)

Publications
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These publications cite the use of CX 614 purchased from Hello Bio:

  • Positive modulation of AMPA receptors increases neurotrophin expression by hippocampal and cortical neurons.

    Lauterborn JC et al (2000) The Journal of neuroscience : the official journal of the Society for Neuroscience 20 : 8-21
    PubMedID: 10627576

1 Item

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Grouped product items
Order: HB1568
Pack PriceQty
10mg
$130
50mg
$538

AMPA receptor positive allosteric modulator (PAM)

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Standard: $35

Hazardous: $35

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