Great product - L-AP4 arrived in time for experiments. Excellent documentation and ease of use. Data looks promising from experiments - happy customer! Verified customer, The University of Newcastle
Description
L-AP4 is a selective group III mGluR agonist which inhibits synaptic transmission.
L-AP4 is a selective group III mGluR agonist (EC50 values are 0.9, 252, 0.06-0.6 μM at mGlu4, mGlu7, mGlu8 receptors respectively and >1000 μM at other mGluRs) and also a weak NMDA receptor agonist.
L-AP4 is a potent synaptic depressant.
L-AP4 reduces glutamate release, inhibits glutamate-mediated EPSPs in the hippocampus, olfactory cortex and spinal cord and inhibits long term potentiation (LTP) in vivo.
Additionally, L-AP4 also inhibits GABA release and reversibly reduces GABA-mediated inhibitory post-synaptic potential (IPSP) amplitude.
L-AP4 also shows neuroprotective properties.
Solubility & Handling
Storage instructions
Room temperature
Solubility overview
Soluble in water (5mM) and in 0.1M NaOH (100mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
![L-AP4 [23052-81-5] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0370.png "L-AP4 [23052-81-5]")
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