L-AP4

(HB0370)
Technical documents: SDS CoA Datasheet

Product overview

Name L-AP4
Description L-AP4 is a selective group III mGluR agonist which inhibits synaptic transmission.
Purity >99%
Customer comments

Great product - L-AP4 arrived in time for experiments. Excellent documentation and ease of use. Data looks promising from experiments - happy customer! Verified customer, The University of Newcastle

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Biological Data

Biological description

L-AP4 is a selective group III mGluR agonist (EC50 values are 0.9, 252, 0.06-0.6 μM at mGlu4, mGlu7, mGlu8 receptors respectively and >1000 μM at other mGluRs) and also a weak NMDA receptor agonist.


L-AP4 is a potent synaptic depressant.


L-AP4 reduces glutamate release, inhibits glutamate-mediated EPSPs in the hippocampus, olfactory cortex and spinal cord and inhibits long term potentiation (LTP) in vivo.


Additionally, L-AP4 also inhibits GABA release and reversibly reduces GABA-mediated inhibitory post-synaptic potential (IPSP) amplitude.


L-AP4 also shows neuroprotective properties.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in water (5mM) and in 0.1M NaOH (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name L-(+)-2-Amino-4-phosphonobutyric acid
Molecular Weight 183.1
Chemical structure L-AP4  [23052-81-5] Chemical Structure
Molecular Formula C4H10NO5P
CAS Number 23052-81-5
PubChem identifier 179394
SMILES C(CP(=O)(O)O)[C@@H](C(=O)O)N
Source Synthetic
InChi InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
InChiKey DDOQBQRIEWHWBT-VKHMYHEASA-N
MDL number MFCD00083244
Appearance White solid

References for L-AP4

References are publications that support the biological activity of the product
  • Changes of mGluR4 and the effects of its specific agonist L-AP4 in a rodent model of diffuse brain injury.

    Zhou F et al (2003) J Clin Neurosci 10(6) : 684-8.
  • L-AP4, a potent agonist of group III metabotropic glutamate receptor, decreases central action of angiotensin II.

    Fedosiewicz-Wasiluk M et al (2002) Pol J Pharmacol 54(5) : 415-22.
  • Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system.

    Schoepp DD (2001) J Pharmacol Exp Ther 299(1) : 12-20.
  • The agonist selectivity of a class III metabotropic glutamate receptor, human mGluR4a, is determined by the N-terminal extracellular domain.

    Tones MA et al (1995) Neuroreport 7(1) : 117-20.
Publications
These publications cite the use of L-AP4 purchased from Hello Bio:
  • Expression of GluA2-containing calcium-impermeable AMPA receptors on dopaminergic amacrine cells in the mouse retina

    Liu LL et al (2019) Mol Vis 25 : 780-790
    PubMedID: 31819340
  • NMDA receptors contribute to retrograde synaptic transmission from ganglion cell photoreceptors to dopaminergic amacrine cells

    Liu et al (2017) Frontier in Cellular Neuroscience 11:279 : (1-13)

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