|Description|| L-AP4 is a selective group III mGluR agonist which inhibits synaptic transmission. |
|Customer comments|| |
Great product - L-AP4 arrived in time for experiments. Excellent documentation and ease of use. Data looks promising from experiments - happy customer! Verified customer, The University of Newcastle
|Biological description|| |
L-AP4 is a selective group III mGluR agonist (EC50 values are 0.9, 252, 0.06-0.6 μM at mGlu4, mGlu7, mGlu8 receptors respectively and >1000 μM at other mGluRs) and also a weak NMDA receptor agonist.
L-AP4 is a potent synaptic depressant.
L-AP4 reduces glutamate release, inhibits glutamate-mediated EPSPs in the hippocampus, olfactory cortex and spinal cord and inhibits long term potentiation (LTP) in vivo.
Additionally, L-AP4 also inhibits GABA release and reversibly reduces GABA-mediated inhibitory post-synaptic potential (IPSP) amplitude.
L-AP4 also shows neuroprotective properties.
Solubility & Handling
|Storage instructions|| Room temperature |
|Solubility overview|| Soluble in water (5mM) and in 0.1M NaOH (100mM) |
|Important|| This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
|Chemical name|| L-(+)-2-Amino-4-phosphonobutyric acid |
|Chemical structure|| |
|Molecular Formula|| C4H10NO5P |
|PubChem identifier|| 179394 |
|SMILES|| C(CP(=O)(O)O)[C@@H](C(=O)O)N |
|InChi|| InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1 |
|InChiKey|| DDOQBQRIEWHWBT-VKHMYHEASA-N |
References for L-AP4
References are publications that support the biological activity of the product
Changes of mGluR4 and the effects of its specific agonist L-AP4 in a rodent model of diffuse brain injury.
Zhou F et al (2003) J Clin Neurosci 10(6) : 684-8.
L-AP4, a potent agonist of group III metabotropic glutamate receptor, decreases central action of angiotensin II.
Fedosiewicz-Wasiluk M et al (2002) Pol J Pharmacol 54(5) : 415-22.
Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system.
Schoepp DD (2001) J Pharmacol Exp Ther 299(1) : 12-20.
The agonist selectivity of a class III metabotropic glutamate receptor, human mGluR4a, is determined by the N-terminal extracellular domain.
Tones MA et al (1995) Neuroreport 7(1) : 117-20.
These publications cite the use of L-AP4 purchased from Hello Bio:
Expression of GluA2-containing calcium-impermeable AMPA receptors on dopaminergic amacrine cells in the mouse retina
Liu LL et al (2019) Mol Vis 25 : 780-790
NMDA receptors contribute to retrograde synaptic transmission from ganglion cell photoreceptors to dopaminergic amacrine cells
Liu et al (2017) Frontier in Cellular Neuroscience 11:279 : (1-13)