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Images (S)-MCPG product vial image | Hello Bio
(S)-MCPG product vial image | Hello Bio Biological Data Biological description Non-selective group I and II mGluR antagonist. Water soluble sodium salt.
Active enantiomer of (R,S)-MCPG .
8 receptor but none at mGlu4 receptor.
Inhibits MF-LTP (mossy fiber long term potentiation) and blocks induction of LTP in CA1 of rat hippocampus.
(R,S)-MCPG sodium salt and (S)-MCPG sodium salt also available.
Solubility & Handling Solubility overview Soluble in 0.1M NaOH (100mM)
Storage instructions Room temperature
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name (S )-α-Methyl-4-carboxyphenylglycine
Chemical structure
Molecular Formula C10 H11 NO4
PubChem identifier 446355
SMILES C[C@](C1=CC=C(C=C1)C(=O)O)(C(=O)O)N
InChi InChI=1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15)/t10-/m0/s1
InChiKey DNCAZYRLRMTVSF-JTQLQIEISA-N
References for (S)-MCPG References are publications that support the biological activity of the product
Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Schoepp DD et al (1999) Neuropharmacology 38(10) : 1431-76. Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Sekiyama N et al (1996) Br J Pharmacol 117(7) : 1493-503. Structure-activity relationships for a series of phenylglycine derivatives acting at metabotropic glutamate receptors (mGluRs). Bedingfield JS et al (1995) Br J Pharmacol 116(8) : 3323-9.
Publications
These publications cite the use of (S)-MCPG purchased from Hello Bio:
Synaptotagmin 7 Sculpts Short-Term Plasticity at a High Probability Synapse. Chiu DN et al (2024) The Journal of neuroscience : the official journal of the Society for Neuroscience 44 Gephyrin Interacts with the K-Cl Cotransporter KCC2 to Regulate Its Surface Expression and Function in Cortical Neurons Al Awabdh S et al (2022) J Neurosci 42(2) : 166-182
Non-selective group I/II mGluR antagonist
![(S)-MCPG [150145-89-4] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0056.png "(S)-MCPG [150145-89-4]")
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