Product overview

Name (S)-MCPG
Alternative names (S)-M4CPG
Purity >99%
Description Non-selective group I/II mGluR antagonist
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(S)-MCPG product vial image | Hello Bio

Biological Data

Biological description

Non-selective group I and II mGluR antagonist. Water soluble sodium salt.

Active enantiomer of (R,S)-MCPG.

Displays slight activity at mGlu8 receptor but none at mGlu4 receptor.

Inhibits MF-LTP (mossy fiber long term potentiation) and blocks induction of LTP in CA1 of rat hippocampus.

Water soluble (R,S)-MCPG sodium salt and (S)-MCPG sodium salt also available.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in 0.1M NaOH (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >99%
Chemical name (S)-α-Methyl-4-carboxyphenylglycine
Molecular Weight 209.2
Chemical structure (S)-MCPG  [150145-89-4] Chemical Structure
Molecular Formula C10H11NO4
CAS Number 150145-89-4
PubChem identifier 446355
SMILES C[C@](C1=CC=C(C=C1)C(=O)O)(C(=O)O)N
Source Synthetic
InChi InChI=1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15)/t10-/m0/s1
MDL number MFCD00216858
Appearance White solid

References for (S)-MCPG

References are publications that support the biological activity of the product
  • Pharmacological agents acting at subtypes of metabotropic glutamate receptors.

    Schoepp DD et al (1999) Neuropharmacology 38(10) : 1431-76.
  • Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes.

    Sekiyama N et al (1996) Br J Pharmacol 117(7) : 1493-503.
  • Structure-activity relationships for a series of phenylglycine derivatives acting at metabotropic glutamate receptors (mGluRs).

    Bedingfield JS et al (1995) Br J Pharmacol 116(8) : 3323-9.

3 Item(s)

These publications cite the use of (S)-MCPG purchased from Hello Bio:
  • Gephyrin Interacts with the K-Cl Cotransporter KCC2 to Regulate Its Surface Expression and Function in Cortical Neurons

    Al Awabdh S et al (2022) J Neurosci 42(2) : 166-182
    PubMedID: 34810232

1 Item