Product overview
| Name | (S)-MCPG |
| Description | Non-selective group I/II mGluR antagonist |
| Alternative names | (S)-M4CPG |
| Purity | >99% |
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Biological Data
| Biological description | Non-selective group I and II mGluR antagonist. Water soluble sodium salt. Active enantiomer of (R,S)-MCPG.
Inhibits MF-LTP (mossy fiber long term potentiation) and blocks induction of LTP in CA1 of rat hippocampus.
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Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in 0.1M NaOH (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | (S)-α-Methyl-4-carboxyphenylglycine |
| Molecular Weight | 209.2 |
| Chemical structure | ![(S)-MCPG [150145-89-4] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0056.png "(S)-MCPG [150145-89-4]") |
| Molecular Formula | C10H11NO4 |
| CAS Number | 150145-89-4 |
| PubChem identifier | 446355 |
| SMILES | C[C@](C1=CC=C(C=C1)C(=O)O)(C(=O)O)N |
| Source | Synthetic |
| InChi | InChI=1S/C10H11NO4/c1-10(11,9(14)15)7-4-2-6(3-5-7)8(12)13/h2-5H,11H2,1H3,(H,12,13)(H,14,15)/t10-/m0/s1 |
| InChiKey | DNCAZYRLRMTVSF-JTQLQIEISA-N |
| MDL number | MFCD00216858 |
| Appearance | White solid |
References for (S)-MCPG
References are publications that support the biological activity of the product
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Pharmacological agents acting at subtypes of metabotropic glutamate receptors.
Schoepp DD et al (1999) Neuropharmacology 38(10) : 1431-76. -
Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes.
Sekiyama N et al (1996) Br J Pharmacol 117(7) : 1493-503. -
Structure-activity relationships for a series of phenylglycine derivatives acting at metabotropic glutamate receptors (mGluRs).
Bedingfield JS et al (1995) Br J Pharmacol 116(8) : 3323-9.
Publications
These publications cite the use of (S)-MCPG purchased from Hello Bio:
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Gephyrin Interacts with the K-Cl Cotransporter KCC2 to Regulate Its Surface Expression and Function in Cortical Neurons
Al Awabdh S et al (2022) J Neurosci 42(2) : 166-182PubMedID: 34810232
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