Product overview

Name (R,S)-MCPG sodium salt
Purity >98%
Description Water soluble, non-selective group I and II mGluR antagonist
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Biological Data

Biological description

Water soluble non-selective group I and II mGluR antagonist.

Also competitive antagonist of ACPD sensitive receptors.

Shows no effect on locomotor activity.

(R,S)-MCPG and (S)-MCPG sodium salt also available. (S)-MCPG also available.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name (RS)-α-Methyl-4-carboxyphenylglycine disodium salt
Molecular Weight 253.16
Chemical structure (R,S)-MCPG sodium salt  [1303994-09-3] Chemical Structure
Molecular Formula C10H9NNa2O4
CAS Number 1303994-09-3
PubChem identifier 90488871
SMILES NC(C)(C(=O)O[Na])c1ccc(cc1)C(=O)O
Source Synthetic
Appearance White solid

References for (R,S)-MCPG sodium salt

References are publications that support the biological activity of the product
  • The metabotropic glutamate receptor antagonist (RS)-MCPG produces hyperlocomotion in amphetamine pre-exposed rats.

    Kim JH et al (1998) Neuropharmacology 37(2) : 189-97.
  • MCPG antagonizes metabotropic glutamate receptors but not long-term potentiation in the hippocampus.

    Manzoni OJ et al (1994) Eur J Neurosci 6(6) : 1050-4.
  • Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine and (RS)-alpha-methyl-4-carboxyphenylglycine.

    Eaton SA et al (1993) Eur J Pharmacol 244(2) : 195-7.

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