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Biological Data
| Biological description | Non-selective group I and II mGluR antagonist. Water soluble sodium salt.
Active enantiomer of (R,S)-MCPG.
Displays slight activity at mGlu8 receptor but none at mGlu4 receptor.
Inhibits MF-LTP (mossy fiber long term potentiation) and blocks induction of LTP in CA1 of rat hippocampus.
(S)-MCPG and (R,S)-MCPG sodium salt also available.
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Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in water (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | (S)-α-Methyl-4-carboxyphenylglycine sodium salt |
| Chemical structure |  |
| Molecular Formula | C10H10NNaO4 |
| SMILES | C[C@@]([NH3+])(C([O-])=O)c1ccc(cc1)C([O-])=O |
References for (S)-MCPG sodium salt
References are publications that support the biological activity of the product
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Pharmacological agents acting at subtypes of metabotropic glutamate receptors.
Schoepp DD et al (1999) Neuropharmacology 38(10) : 1431-76. -
Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes.
Sekiyama N et al (1996) Br J Pharmacol 117(7) : 1493-503. -
Structure-activity relationships for a series of phenylglycine derivatives acting at metabotropic glutamate receptors (mGluRs).
Bedingfield JS et al (1995) Br J Pharmacol 116(8) : 3323-9.
Non-selective group I and II mGluR antagonist. Water soluble sodium salt.
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