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Biological Data Biological description Non-selective group I and II mGluR antagonist. Water soluble sodium salt.
Active enantiomer of (R,S)-MCPG .
8 receptor but none at mGlu4 receptor.
Inhibits MF-LTP (mossy fiber long term potentiation) and blocks induction of LTP in CA1 of rat hippocampus.
(S)-MCPG and (R,S)-MCPG sodium salt also available.
Solubility & Handling Solubility overview Soluble in water (100mM)
Storage instructions Room temperature
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name (S)-α-Methyl-4-carboxyphenylglycine sodium salt
Chemical structure
Molecular Formula C10 H10 NNaO4
SMILES C[C@@]([NH3+])(C([O-])=O)c1ccc(cc1)C([O-])=O
References for (S)-MCPG sodium salt References are publications that support the biological activity of the product
Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Schoepp DD et al (1999) Neuropharmacology 38(10) : 1431-76. Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Sekiyama N et al (1996) Br J Pharmacol 117(7) : 1493-503. Structure-activity relationships for a series of phenylglycine derivatives acting at metabotropic glutamate receptors (mGluRs). Bedingfield JS et al (1995) Br J Pharmacol 116(8) : 3323-9.
Non-selective group I and II mGluR antagonist. Water soluble sodium salt.
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