Product overview

Name (S)-MCPG sodium salt
Purity >99%
Description Non-selective group I and II mGluR antagonist. Water soluble sodium salt.
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Biological Data

Biological description

Non-selective group I and II mGluR antagonist. Water soluble sodium salt.

Active enantiomer of (R,S)-MCPG.

Displays slight activity at mGlu8 receptor but none at mGlu4 receptor.

Inhibits MF-LTP (mossy fiber long term potentiation) and blocks induction of LTP in CA1 of rat hippocampus.

(S)-MCPG and (R,S)-MCPG sodium salt also available.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >99%
Chemical name (S)-α-Methyl-4-carboxyphenylglycine sodium salt
Molecular Weight 231.18
Chemical structure S-MCPG | Hello Bio Chemical Structure
Molecular Formula C10H10NNaO4
CAS Number 150145-89-4
SMILES C[C@@]([NH3+])(C([O-])=O)c1ccc(cc1)C([O-])=O
Source Syntheitc
Appearance White solid

References for (S)-MCPG sodium salt

References are publications that support the biological activity of the product
  • Pharmacological agents acting at subtypes of metabotropic glutamate receptors.

    Schoepp DD et al (1999) Neuropharmacology 38(10) : 1431-76.
  • Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes.

    Sekiyama N et al (1996) Br J Pharmacol 117(7) : 1493-503.
  • Structure-activity relationships for a series of phenylglycine derivatives acting at metabotropic glutamate receptors (mGluRs).

    Bedingfield JS et al (1995) Br J Pharmacol 116(8) : 3323-9.

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