My Cart
My account
Menu
Main Menu

Ro 25-6981 maleate

(HB0554)
Publications (6)
Technical documents: SDS CoA Datasheet
5  Reviews
Top Reviews:
100% of 100
Add Your Review
Add to Wish List

Product overview

Name Ro 25-6981 maleate
Purity >98%
Description Selective negative allosteric modulator of GluN2B (NR2B) containing NMDARs
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (4) Reviews (5) Publications (6) References (3) Frequently bought together
Write Your Own Review
You're reviewing:Ro 25-6981 maleate
Rate this item:

Images

Ro 25-6981 maleate product vial image | Hello Bio
Ro 25-6981 maleate product vial image | Hello Bio

Ro 25-6981 maleate product vial image | Hello Bio

Ro 25-6981 maleate product vial image | Hello Bio

Biological Data

Biological description

Ro 25-6981 maleate is a selective negative allosteric modulator (NAM) of GluN2B (NR2B) containing NMDARs.

Ro 25-6981 maleate exhibits >5000-fold selectivity at GluN1C-GluN2B over GluN1C-GluN2A (IC50 values are 9 nM and 52 µM). Ro 25-6981 maleate shows neuroprotective properties.

Solubility & Handling

Solubility overview Soluble in water (10mM, gentle warming) and in DMSO (100mM)
Storage instructions Room temperature (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Handling Hydroscopic solid, contact with air may cause material to become sticky. Product performance should not be affected but we recommend storing the material in a sealed jar.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Purity >98%
Chemical name (αR,βS)-α-(4-Hydroxyphenyl)-β-methyl-4- (phenylmethyl)-1-piperidinepropanol maleate
Molecular Weight 455.55
Chemical structure Ro 25-6981 [1312991-76-6] Chemical Structure
Molecular Formula C22H29NO2.C4H4O4
CAS Number 1312991-76-6
PubChem identifier 53250677
SMILES C[C@@H](CN1CCC(CC1)CC2=CC=CC=C2)[C@H](C3=CC=C(C=C3)O)O.C(=C\C(=O)O)\C(=O)O
Source Synthetic
InChi InChI=1S/C22H29NO2.C4H4O4/c1-17(22(25)20-7-9-21(24)10-8-20)16-23-13-11-19(12-14-23)15-18-5-3-2-4-6-18;5-3(6)1-2-4(7)8/h2-10,17,19,22,24-25H,11-16H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t17-,22+;/m0./s1
InChiKey FYJZEHCQSUBZDY-SEELMCCHSA-N
MDL number MFCD06798375
Appearance White solid

References for Ro 25-6981 maleate

References are publications that support the biological activity of the product

  • The NR2B-selective NMDA receptor antagonist Ro 25-6981 potentiates the effect of nicotine on locomotor activity and DA release in the nucleus

    Kosowski AR et al (2004) J Pharmacol Exp Ther 311(2) : 560-7.
    Read more (PubMedID: 15256539)

  • Pharmacological characterization of interactions of RO 25-6981 with the NR2B (epsilon2) subunit.

    Lynch DR et al (2001) Eur J Pharmacol 416(3) : 185-95.
    Read more (PubMedID: 11290368)

  • Ro 25-6981, a highly potent and selective blocker of NMDA receptors containing the NR2B subunit. Characterization in vitro.

    Fischer G et al (1997) J Pharmacol Exp Ther 283(3) : 1285-92.
    Read more (PubMedID: 9400004)

3 Item(s)

Publications
Submit Yours Now
These publications cite the use of Ro 25-6981 maleate purchased from Hello Bio:

  • Differential Regulation of Evoked and Spontaneous Release by Presynaptic NMDA Receptors

    Abrahamsson et al (2017) Neuron 09 : 030
    PubMedID: 29033205

Items 6 to 6 of 6 total

Page
Related Products
Grouped product items
Order: HB0554
Pack PriceQty
1mg
$64
10mg
$136
50mg
$563
Selective negative allosteric modulator of GluN2B (NR2B) containing NMDARs
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

Contact Us

Call 609-683-7500
Fax 609-228-4994

customercare-usa@hellobio.com

New Products in this Area

CGP 78608 hydrochloride
HB0187

Selective, competitive GluN1 NMDAR receptor antagonist. Enhances GluN1/3 activation.

Related Products

NBQX disodium salt
Code:
HB0443
Pack:
1mg, 10mg, 50mg, 50mM (add 1ml water), 100mM (add 1ml water)
Price:
$93, $193, $816, $460, $801
(Free trial)
Potent, selective, competitive AMPA receptor antagonist. Disodium salt.
Tetrodotoxin citrate
Code:
HB1035
Pack:
1mg
Price:
$267
Potent, selective, use-dependent Na+ channel blocker. Citrate Salt.
D-AP5
Code:
HB0225
Pack:
1mg, 10mg, 50mg, 100mg, 50mM (add 1ml water), 100mM (add 1ml water)
Price:
$45, $116, $495, $685, $161, $289
(Free trial)

Selective, competitive NMDA receptor antagonist. Inhibits NMDAR-synaptic plasticity.