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Images QX 314 bromide: Scientist Approved
QX 314 bromide product vial image | Hello Bio
QX 314 bromide: Scientist Approved
QX 314 bromide product vial image | Hello Bio Biological Data Biological description Membrane impermeable Na+ channel blocker. A quaternary derivative of lidocaine. Reduces amplitude of high threshold Ca2+ currents in CA1 neurons. Displays anesthetic properties. QX 314 chloride also available.
Solubility & Handling Storage instructions Room temperature (desiccate)
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name N -(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium bromide
Chemical structure
Molecular Formula C16 H27 N2 OBr
PubChem identifier 9884487
SMILES CC[N+](CC)(CC)CC(=O)NC1=C(C=CC=C1C)C.[Br-]
InChi InChI=1S/C16H26N2O.BrH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H
InChiKey DLHMKHREUTXMCH-UHFFFAOYSA-N
References for QX 314 bromide References are publications that support the biological activity of the product
Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal neurons. Talbot MJ et al (1996) J Neurophysiol 76(3) : 2120-4. Fast sodium action potentials are generated in the distal apical dendrites of rat hippocampal CA1 pyramidal cells. Colling SB et al (1994) Neurosci Lett 172(1-2) : 73-96. The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine. Strichartz GR (1973) J Gen Physiol 62(1) : 37-57.
Publications
These publications cite the use of QX 314 bromide purchased from Hello Bio:
PAR1 activation induces rapid changes in glutamate uptake and astrocyte morphology. Sweeny et al (2017) Sci Rep. 7 : 43606
Membrane impermeable Na+ channel blocker
![QX 314 bromide [24003-58-5] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1029.png "QX 314 bromide [24003-58-5]")
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