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QX 314 bromide

Technical documents: SDS CoA Datasheet

Product overview

Name QX 314 bromide
Alternative names N-Ethyllidocaine bromide
Purity >98%
Description Membrane impermeable Na+ channel blocker
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QX 314 bromide: Scientist Approved
QX 314 bromide product vial image | Hello Bio

Biological Data

Biological description

Membrane impermeable Na+ channel blocker. A quaternary derivative of lidocaine. Reduces amplitude of high threshold Ca2+ currents in CA1 neurons. Displays anesthetic properties. QX 314 chloride also available.

Solubility & Handling

Storage instructions Room temperature (desiccate)
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium bromide
Molecular Weight 343.31
Chemical structure QX 314 bromide  [24003-58-5] Chemical Structure
Molecular Formula C16H27N2OBr
CAS Number 24003-58-5
PubChem identifier 9884487
Source Synthetic
InChi InChI=1S/C16H26N2O.BrH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H
Appearance White solid

References for QX 314 bromide

References are publications that support the biological activity of the product
  • Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal neurons.

    Talbot MJ et al (1996) J Neurophysiol 76(3) : 2120-4.
  • Fast sodium action potentials are generated in the distal apical dendrites of rat hippocampal CA1 pyramidal cells.

    Colling SB et al (1994) Neurosci Lett 172(1-2) : 73-96.
  • The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine.

    Strichartz GR (1973) J Gen Physiol 62(1) : 37-57.

3 Item(s)

These publications cite the use of QX 314 bromide purchased from Hello Bio:
  • Astrocytic β-catenin signaling via TCF7L2 regulates synapse development and social behavior.

    Szewczyk LM et al (2023) Molecular psychiatry
    PubMedID: 37798419
  • Two opposing hippocampus to prefrontal cortex pathways for the control of approach and avoidance behaviour

    Sanchez-Bellot C et al (2022) Nat Commun 13(1) : 339
    PubMedID: 35039510
  • Synaptic mechanisms of top-down control in the non-lemniscal inferior colliculus

    Oberle HM et al (2022) Elife 10
    PubMedID: 34989674
  • Patch-Clamp Recording of Low Frequency Stimulation-induced Long-Term Synaptic Depression in Rat Hippocampus Slices During Early and Late Neurodevelopment

    Bertrand C et al (2021) Alcohol Clin Exp Res 45(2) : 351-364
    PubMedID: 33196109
  • Hippocampal ghrelin signalling informs the decision to eat

    MacAskill et al (2021) bioRxiv https://doi.org/10.1101/2021.11.05.467326 : doi

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