QX 314 bromide

(HB1029)
Technical documents: SDS CoA Datasheet

Product overview

Name QX 314 bromide
Description Membrane impermeable Na+ channel blocker
Alternative names N-Ethyllidocaine bromide
Purity >98%
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QX 314 bromide: Scientist Approved
QX 314 bromide vial

Biological Data

Biological description

Membrane impermeable Na+ channel blocker. A quaternary derivative of lidocaine. Reduces amplitude of high threshold Ca2+ currents in CA1 neurons. Displays anesthetic properties. QX 314 chloride also available.

Solubility & Handling

Storage instructions Room temperature (desiccate)
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium bromide
Molecular Weight 343.31
Chemical structure QX 314 bromide  [24003-58-5] Chemical Structure
Molecular Formula C16H27N2OBr
CAS Number 24003-58-5
PubChem identifier 9884487
SMILES CC[N+](CC)(CC)CC(=O)NC1=C(C=CC=C1C)C.[Br-]
Source Synthetic
InChi InChI=1S/C16H26N2O.BrH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H
InChiKey DLHMKHREUTXMCH-UHFFFAOYSA-N
Appearance White solid

References for QX 314 bromide

References are publications that support the biological activity of the product
  • Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal neurons.

    Talbot MJ et al (1996) J Neurophysiol 76(3) : 2120-4.
  • Fast sodium action potentials are generated in the distal apical dendrites of rat hippocampal CA1 pyramidal cells.

    Colling SB et al (1994) Neurosci Lett 172(1-2) : 73-96.
  • The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine.

    Strichartz GR (1973) J Gen Physiol 62(1) : 37-57.
Publications
These publications cite the use of QX 314 bromide purchased from Hello Bio:
  • PTC-174, a positive allosteric modulator of NMDA receptors containing GluN2C or GluN2D subunits

    Yi F et al (2020) Neuropharmacology 25 : 107971
    PubMedID: 31987864
  • Spiny and Non-spiny Parvalbumin-Positive Hippocampal Interneurons Show Different Plastic Properties

    Foggetti A et al (2019) Cell Rep : 3725-3732.e5
    PubMedID: 31242406
  • Postnatal Development of Neural Networks in the Healthy and Premature Brain

    Cross, C. (2018) University of Bristol Thesis : 1-308
  • Activation of TRPC1 Channel by Metabotropic Glutamate Receptor mGluR5 Modulates Synaptic Plasticity and Spatial Working Memory

    Lepennetier et al (2018) Front. Cell. Neurosci. https://doi.org/ : 10.3389/fncel.2018.00318
  • PAR1 activation induces rapid changes in glutamate uptake and astrocyte morphology.

    Sweeny et al (2017) Sci Rep. 7 : 43606
    PubMedID: 28256580

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