Product overview
Name | QX 314 chloride |
Description | Membrane impermeable Na+ channel blocker |
Alternative names | N-Ethyllidocaine chloride |
Purity | >98% |
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Biological Data
Biological description | Membrane impermeable Na+ channel blocker. A quaternary derivative of lidocaine. Displays anesthetic properties. Active in vivo. QX 314 bromide also available. |
Application notes | #Figure 1: QX 314 inhibition of action potentials in rat CA1 pyramidal neurones during dendritic plateau potentials QX 314 is a membrane impermeable Na+ channel blocker commonly used to inhibit action potential formation. QX 314 from Hello Bio inhibits the ability for action potentials to generate in two different cells during dendritic plateau potentials at 1mM (see Fig 1 above).
#Protocol 1: Evoked plateau potentials in rat CA1 pyramidal neurones
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Solubility & Handling
Storage instructions | Room temperature |
Solubility overview | Soluble in water (100mM) |
Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
Chemical name | N-(2,6-Dimethylphenylcarbamoylmethyl)triethylammonium chloride |
Molecular Weight | 298.85 |
Chemical structure | |
Molecular Formula | C16H27N2OCl |
CAS Number | 5369-03-9 |
PubChem identifier | 21462 |
SMILES | CC[N+](CC)(CC)CC(=O)NC1=C(C=CC=C1C)C.[Cl-] |
Source | Synthetic |
InChi | InChI=1S/C16H26N2O.ClH/c1-6-18(7-2,8-3)12-15(19)17-16-13(4)10-9-11-14(16)5;/h9-11H,6-8,12H2,1-5H3;1H |
InChiKey | LLPPOMUAOGMYQI-UHFFFAOYSA-N |
MDL number | MFCD01669894 |
Appearance | White solid |
References for QX 314 chloride
References are publications that support the biological activity of the product
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Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal neurons.
Talbot MJ et al (1996) J Neurophysiol 76(3) : 2120-4. -
Fast sodium action potentials are generated in the distal apical dendrites of rat hippocampal CA1 pyramidal cells.
Colling SB et al (1994) Neurosci Lett 172(1-2) : 73-96.
Publications
These publications cite the use of QX 314 chloride purchased from Hello Bio:
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Mild stress accumulation limits GABAergic synaptic plasticity in the lateral habenula
Lalive AL et al (2022) Eur J Neurosci 55(2) : 377-387PubMedID: 34963191 -
Enhancement of parvalbumin interneuron-mediated neurotransmission in the retrosplenial cortex of adolescent mice following third trimester-equivalent ethanol exposure
Bird CW et al (2021) Sci Rep 11(1) : 1716PubMedID: 33462326 -
Synaptic inhibition in the lateral habenula shapes reward anticipation
Mameli et al (2021) bioRxiv . : https://doi.org/10.1101/2021.01. -
Investigating dichotomous projections from ventral hippocampus to prefrontal cortex
Sanchez Bellot et al (2020) UCL : Thesis -
The Probability of Neurotransmitter Release Governs AMPA Receptor Trafficking via Activity-Dependent Regulation of mGluR1 Surface Expression.
Sanderson et al (2018) Cell Rep. 25(13) : 3631-3646PubMedID: 30590038