DREADD
Designer receptors exclusively activated by designer drugs (DREADDs) are genetically engineered GPCRs that are activated by physiologically inert synthetic small molecules (designer drugs) but not their endogenous ligand. Read our DREADDs mini-review or for practical advice on using these ligands in the lab see Stability of Water-Soluble DREADD Ligands in Solution: A Technical Review and Clozapine N-Oxide (freebase) - a technical review on stability, solubility and use in the lab).
- Description:
Fluorescent M3 muscarinic receptor antagonist
-
-
Olanzapine (HB1786)
Description:5-HT2A and D2 antagonist. Potent DREADD agonist. Atypical antipsychotic.
Purity:>99%
-
PD 102807 (HB1509)
Description:Potent, selective M4 receptor antagonist. Promotes erythroid progenitors expansion.
Purity:>98%
-
Tropisetron hydrochloride (HB2827)
Description:Potent 5-HT3 receptor antagonist. Also α7 nAChR partial agonist. Activates α7Q79G-GlyR chimeric ion channels.
Purity:>99%
![CA200887 CellAura fluorescent M<sub>3</sub> antagonist [pirenzepine]](https://hellobio.com/media/catalog/product/cache/7630ee9852b6c22c7de1165054afc779/h/b/hb7827-ca200887-image1_1.png)
