Olanzapine

Name: Olanzapine
Brand: Hello Bio
SKU: HB1786
Price: 54 USD
Availability: InStock

(HB1786)

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Technical documents: SDS CoA Datasheet

Product overview

Name

Olanzapine

Alternative names

OZP

Purity

>99%

Description

5-HT_2A and D₂ antagonist. Potent DREADD agonist. Atypical antipsychotic.

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) References (3) Frequently bought together

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Biological Data

Biological description

5-HT_2A and D₂ antagonist (K_i values are 4 and 11 nM respectively). Also shows affinity at many other receptors e.g. 5-HT_2C, D₁ / D₄, α1, H₁ and M_1-4 receptors.

Also a potent hM4Di DREADD receptor agonist (EC₅₀ = ~5 nM in vitro.

Atypical antipsychotic which also shows anticholinergic properties.

Solubility & Handling

Storage instructions

+4°C

Solubility overview

Soluble in DMSO (100mM) or water (100mM, 1eq. HCl)

Important

This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

More Info

Dilution

More Info

Chemical Data

Purity

>99%

Chemical name

2-Methyl-4-(4-methyl-1-piperazinyl) -10H-thieno[2,3-b][1,5]benzodiazepine

Molecular Weight

312.43

Chemical structure

Molecular Formula

C₁₇H₂₀N₄S

CAS Number

132539-06-1

PubChem identifier

4585

SMILES

CC1=CC2=C(NC3=CC=CC=C3N=C2S1)N4CCN(CC4)C

InChi

InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,18H,7-10H2,1-2H3

InChiKey

WXPNDRBBWZMPQG-UHFFFAOYSA-N

MDL number

MFCD00866702

Appearance

Yellow solid

Technical guides

Understanding purity and quality - a guide for life scientists (159.4 KB)

DREADDs (Designer Receptors Exclusively Activated by Designer Drugs) mini-review

References for Olanzapine

References are publications that support the biological activity of the product

Olanzapine: A potent agonist at the hM4D(Gi) DREADD amenable to clinical translation of chemogenetics
Weston M et al (2019) Sci Adv : 5(4)
Read more (PubMedID: 31001591)
Radioreceptor binding profile of the atypical antipsychotic olanzapine
Bymaster FP et al (1996) Neuropsychopharmacology 14(2) : 87-96
Read more (PubMedID: 8822531)
The behavioral pharmacology of olanzapine, a novel atypical" antipsychotic agent"
Moore NA et al (1992) J Pharmacol Exp Ther 262(2) : 545-51
Read more (PubMedID: 1354253)

5-HT_2A and D₂ antagonist. Potent DREADD agonist. Atypical antipsychotic.

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Order: HB1786
Pack	Price	Qty
10mg	$54
50mg	$215

Olanzapine

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for Olanzapine

Olanzapine: A potent agonist at the hM4D(Gi) DREADD amenable to clinical translation of chemogenetics

Radioreceptor binding profile of the atypical antipsychotic olanzapine

The behavioral pharmacology of olanzapine, a novel atypical" antipsychotic agent"

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New Products in this Area

Olanzapine

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for Olanzapine

Olanzapine: A potent agonist at the hM4D(Gi) DREADD amenable to clinical translation of chemogenetics

Radioreceptor binding profile of the atypical antipsychotic olanzapine

The behavioral pharmacology of olanzapine, a novel atypical" antipsychotic agent"

About you

Tell us about your publication!

Captcha

About you

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New Products in this Area

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