Product overview

Name Olanzapine
Alternative names OZP
Purity >99%
Description 5-HT2A and D2 antagonist. Potent DREADD agonist. Atypical antipsychotic.
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Biological Data

Biological description

5-HT2A and D2 antagonist (Ki values are 4 and 11 nM respectively). Also shows affinity at many other receptors e.g. 5-HT2C, D1 / D4, α1, H1 and M1-4 receptors.

Also a potent hM4Di DREADD receptor agonist (EC50 = ~5 nM in vitro.

Atypical antipsychotic which also shows anticholinergic properties.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM) or water (100mM, 1eq. HCl)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >99%
Chemical name 2-Methyl-4-(4-methyl-1-piperazinyl) -10H-thieno[2,3-b][1,5]benzodiazepine
Molecular Weight 312.43
Chemical structure Olanzapine [132539-06-1] Chemical Structure
Molecular Formula C17H20N4S
CAS Number 132539-06-1
PubChem identifier 4585
InChi InChI=1S/C17H20N4S/c1-12-11-13-16(21-9-7-20(2)8-10-21)18-14-5-3-4-6-15(14)19-17(13)22-12/h3-6,11,18H,7-10H2,1-2H3
MDL number MFCD00866702
Appearance Yellow solid

References for Olanzapine

References are publications that support the biological activity of the product
  • Olanzapine: A potent agonist at the hM4D(Gi) DREADD amenable to clinical translation of chemogenetics

    Weston M et al (2019) Sci Adv : 5(4)
  • Radioreceptor binding profile of the atypical antipsychotic olanzapine

    Bymaster FP et al (1996) Neuropsychopharmacology 14(2) : 87-96
  • The behavioral pharmacology of olanzapine, a novel atypical" antipsychotic agent"

    Moore NA et al (1992) J Pharmacol Exp Ther 262(2) : 545-51

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