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PD 102807

(HB1509)
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Product overview

Name PD 102807
Purity >98%
Description Potent, selective M4 receptor antagonist. Promotes erythroid progenitors expansion.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews References (4) Frequently bought together
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Biological Data

Biological description Potent and selective M4 muscarinic receptor antagonist (IC50 = 90.7 nM). Shows 72-, 38-, 10- and 82-fold selectivey for M4 over M1, M2, M3 and M5 receptors respectively. Also promotes erythroid progenitors expansion.

Solubility & Handling

Solubility overview Soluble in DMSO (100mM)
Storage instructions

Room temperature

Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 3,6a,11,14-Tetrahydro-9-methoxy-2-methyl-(12H)-isoquino[1,2-b]pyrrolo[3,2-f][1,3]benzoxazine-1-carboxylic acid, ethyl ester
Molecular Weight 392.45
Chemical structure PD 102807 [23062-91-1] Chemical Structure
Molecular Formula C23H24N2O4
CAS Number 23062-91-1
PubChem identifier 4995951
SMILES CCOC(=O)C1=C(NC2=C1C3=C(C=C2)OC4C5=C(CCN4C3)C=C(C=C5)OC)C
InChi InChI=1S/C23H24N2O4/c1-4-28-23(26)20-13(2)24-18-7-8-19-17(21(18)20)12-25-10-9-14-11-15(27-3)5-6-16(14)22(25)29-19/h5-8,11,22,24H,4,9-10,12H2,1-3H3
InChiKey VDDUJINYXKGZLV-UHFFFAOYSA-N

References for PD 102807

References are publications that support the biological activity of the product

  • Muscarinic modulation of synaptic transmission via endocannabinoid signalling in the rat midbrain periaqueductal gray.

    Lau BK et al (2008) Mol Pharmacol 74(5) : 1392-8.
    Read more (PubMedID: 18678620)

  • Synthesis and pharmacology of benzoxazines as highly selective antagonists at M(4) muscarinic receptors.

    Bã?hme TM et al (2002) J Med Chem 45(14) : 3094-102.
    Read more (PubMedID: 12086495)

  • A novel muscarinic M(4) receptor antagonist provides further evidence of an autoreceptor role for the muscarinic M(2) receptor sub-type.

    Kitaichi K et al (1999) Eur J Pharmacol 383(1) : 53-6.
    Read more (PubMedID: 10556681)

  • Identification and characterization of m4 selective muscarinic antagonists.

    Augelli-Szafran CE et al (1998) Bioorg Med Chem Lett 8(15) : 1991-6.
    Read more (PubMedID: 9873472)

4 Item(s)

Grouped product items
Order: HB1509
Pack PriceQty
10mg
$300
Potent, selective M4 receptor antagonist. Promotes erythroid progenitors expansion.
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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