Product overview

Name PD 102807
Purity >98%
Description Potent, selective M4 receptor antagonist. Promotes erythroid progenitors expansion.
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Biological Data

Biological description Potent and selective M4 muscarinic receptor antagonist (IC50 = 90.7 nM). Shows 72-, 38-, 10- and 82-fold selectivey for M4 over M1, M2, M3 and M5 receptors respectively. Also promotes erythroid progenitors expansion.

Solubility & Handling

Storage instructions

Room temperature

Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name 3,6a,11,14-Tetrahydro-9-methoxy-2-methyl-(12H)-isoquino[1,2-b]pyrrolo[3,2-f][1,3]benzoxazine-1-carboxylic acid, ethyl ester
Molecular Weight 392.45
Chemical structure PD 102807  [23062-91-1] Chemical Structure
Molecular Formula C23H24N2O4
CAS Number 23062-91-1
PubChem identifier 4995951
InChi InChI=1S/C23H24N2O4/c1-4-28-23(26)20-13(2)24-18-7-8-19-17(21(18)20)12-25-10-9-14-11-15(27-3)5-6-16(14)22(25)29-19/h5-8,11,22,24H,4,9-10,12H2,1-3H3

References for PD 102807

References are publications that support the biological activity of the product
  • Muscarinic modulation of synaptic transmission via endocannabinoid signalling in the rat midbrain periaqueductal gray.

    Lau BK et al (2008) Mol Pharmacol 74(5) : 1392-8.
  • Synthesis and pharmacology of benzoxazines as highly selective antagonists at M(4) muscarinic receptors.

    Bã?hme TM et al (2002) J Med Chem 45(14) : 3094-102.
  • A novel muscarinic M(4) receptor antagonist provides further evidence of an autoreceptor role for the muscarinic M(2) receptor sub-type.

    Kitaichi K et al (1999) Eur J Pharmacol 383(1) : 53-6.
  • Identification and characterization of m4 selective muscarinic antagonists.

    Augelli-Szafran CE et al (1998) Bioorg Med Chem Lett 8(15) : 1991-6.

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