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Biological Data

Biological description Selective M3 muscarinic receptor antagonist. Blocks [3H]-scopolamine binding to muscle cells expressing M3 and M2 (IC50 values are 0.4 nM and 15 µM respectively).

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (25mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Chemical name 1,1-Dimethyl-4-diphenylacetoxypiperidinium iodide
Molecular Weight 451.33
Chemical structure 4-DAMP  [1952-15-4] Chemical Structure
Molecular Formula C21H26INO2
CAS Number 1952-15-4
PubChem identifier 3014059
SMILES [I-].C[N+]1(C)CCC(CC1)OC(=O)C(C1=CC=CC=C1)C1=CC=CC=C1
InChi InChI=1S/C21H26NO2.HI/c1-22(2)15-13-19(14-16-22)24-21(23)20(17-9-5-3-6-10-17)18-11-7-4-8-12-18;/h3-12,19-20H,13-16H2,1-2H3;1H/q+1;/p-1
InChiKey WWJHRSCUAQPFQO-UHFFFAOYSA-M
MDL number MFCD00078564
Appearance White solid

References for 4-DAMP

References are publications that support the biological activity of the product
  • The use of a modified [3H]4-DAMP radioligand binding assay with increased selectivity for muscarinic M3 receptor shows that cortical CHRM3 levels are not altered in mood disorders.

    Jeon WJ et al (2013) Prog Neuropsychopharmacol Biol Psychiatry 47 : 7-12.
  • Differential coupling of muscarinic m2 and m3 receptors to adenylyl cyclases V/VI in smooth muscle. Concurrent M2-mediated inhibition via Galphai3 and m3-mediated stimulation via Gbetagammaq.

    Murthy KS et al (1997) J Biol Chem 272(34) : 21317-24.
  • Regional binding of 4-diphenylacetoxy-N-methylpiperidine methobromide (4-DAMP) to muscarinic receptors in rat brain and comparative analysis of minimum energy conformations.

    Collins D et al (1993) Neurochem Int 22(3) : 237-47.