Prazosin hydrochloride

(HB2767)
Technical documents: SDS CoA Datasheet

Product overview

Name Prazosin hydrochloride
Description α1 and α2 adrenoceptor antagonist
Purity >99%
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Biological Data

Biological description α1 and α2 adrenoceptor antagonist (Ki values are 0.32, 0.19 and 0.27 nM respectively). Also shows selective activity at MT3 melatonin receptor. Shows variety of biological actions.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (25mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name 1-(4-Amino-6,7-dimethoxy-2-quinazol inyl)-4-(2-furanylcarbonyl)piperazine hydrochloride
Molecular Weight 419.87
Chemical structure Prazosin hydrochloride [19237-84-4] Chemical Structure
Molecular Formula C19H21N5O4.HCl
CAS Number 19237-84-4
PubChem identifier 68546
SMILES COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC=CO4)N)OC.Cl
InChi InChI=1S/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H
InChiKey WFXFYZULCQKPIP-UHFFFAOYSA-N
MDL number MFCD00058177

References for Prazosin hydrochloride

References are publications that support the biological activity of the product
  • Prazosin Inhibits MK-801-induced Hyperlocomotion and Dopamine Release in the Nucleus Accumbens

    Mathe et al (1996) Eur J Pharmacol 309(1) : 1-11
  • Pharmacological Characterization of Melatonin Binding Sites in Syrian Hamster Hypothalamus

    Pickering and Niles (1990) Eur J Pharmacol 175(1) : 71-7
  • The Pharmacology of Prazosin, a Novel Antihypertensive Agent

    Cavero (1980) Life Sci 27(17) : 1525-40