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Biological Data
| Biological description | AMPA receptor antagonist. Non-selective inhibitor of homomeric GluA1 and GluA3 subunit-containing receptors and heteromeric receptor GluA1/2 subunits (IC50 = 22 µM). |
Solubility & Handling
| Storage instructions | Room temperature (desiccate) |
| Solubility overview | Soluble in water (100mM) or DMSO (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | (S)-N-[7-[(4-Aminobutyl)amino]heptyl]-4-hydroxy-α-[(1-oxobutyl)amino]benzenepropanamide dihydrochloride |
| Chemical structure | ![Philanthotoxin-7,4 [1227301-51-0] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Philanthotoxin-7,4 [1227301-51-0]") |
| Molecular Formula | C24H42N4O3.2HCl |
| PubChem identifier | 46213501 |
| SMILES | Cl.Cl.Oc1ccc(C[C@H](NC(=O)CCC)C(=O)NCCCCCCCNCCCCN)cc1 |
| InChiKey | HWTJQQMIKVJWLH-IKXQUJFKSA-N |
References for Philanthotoxin-7,4
References are publications that support the biological activity of the product
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Evaluation of PhTX-74 as subtype-selective inhibitor of GluA2-containing AMPA receptors.
Poulsen MH et al (2014) Mol Pharmacol 85(2) : 261-8. -
A subtype-selective, use-dependent inhibitor of native AMPA receptors.
Nilsen A et al (2007) J Am Chem Soc 129(16) : 4902-3. -
Solid-phase synthesis of polyamine toxin analogues: potent and selective antagonists of Ca2+-permeable AMPA receptors.
Kromann H et al (2002) J Med Chem 45(26) : 5745-54.
![Philanthotoxin-7,4 [1227301-51-0] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0499.png "Philanthotoxin-7,4 [1227301-51-0]")
Understanding purity and quality - a guide for life scientists
