Product overview

Name Philanthotoxin-7,4
Description AMPA receptor antagonist
Alternative names PhTx-74
Purity >98%
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Biological Data

Biological description AMPA receptor antagonist. Non-selective inhibitor of homomeric GluA1 and GluA3 subunit-containing receptors and heteromeric receptor GluA1/2 subunits (IC50 = 22 µM).

Solubility & Handling

Storage instructions room temperature (desiccate)
Solubility overview Soluble in water (100mM) or DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name (S)-N-[7-[(4-Aminobutyl)amino]heptyl]-4-hydroxy-α-[(1-oxobutyl)amino]benzenepropanamide dihydrochloride
Molecular Weight 507.54
Chemical structure Philanthotoxin-7,4  [1227301-51-0] Chemical Structure
Molecular Formula C24H42N4O3.2HCl
CAS Number 1227301-51-0
PubChem identifier 46213501
SMILES Cl.Cl.Oc1ccc(C[C@H](NC(=O)CCC)C(=O)NCCCCCCCNCCCCN)cc1
InChiKey HWTJQQMIKVJWLH-IKXQUJFKSA-N

References for Philanthotoxin-7,4

References are publications that support the biological activity of the product
  • Evaluation of PhTX-74 as subtype-selective inhibitor of GluA2-containing AMPA receptors.

    Poulsen MH et al (2014) Mol Pharmacol 85(2) : 261-8.
  • A subtype-selective, use-dependent inhibitor of native AMPA receptors.

    Nilsen A et al (2007) J Am Chem Soc 129(16) : 4902-3.
  • Solid-phase synthesis of polyamine toxin analogues: potent and selective antagonists of Ca2+-permeable AMPA receptors.

    Kromann H et al (2002) J Med Chem 45(26) : 5745-54.