Product overview
Name | NBQX disodium salt |
Description | Potent, selective, competitive AMPA receptor antagonist. Disodium salt. |
Purity | >99% |
Customer comments | High quality and affordable! We use this compound routinely in the lab for neuronal recordings. Verified customer, The University of Montana Worked just as it should, results indistinguishable from our previous product but at a significant cost reduction! Verified customer, The University of Toronto Good quality and great price! Verified customer, The University of Newcastle NBQX disodium salt produced by Hello Bio produced a very potent and "clean" block of synaptic AMPA currents, with no effect on other GABAA or NMDA receptors.Verified customer, The University of Edinburgh |
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Biological Data
Biological description | Potent, selective and competitive AMPA receptor antagonist. Also kainate receptor antagonist. Water soluble, disodium salt. Blocks the induction of excitatory post synaptic currents. Shows neuroprotective, antinociceptive and anticonvulsive actions. NBQX also available. |
Application notes | The AMPA receptor antagonist NBQX disodium salt inhibits the actions of glutamate by acting at AMPARs and is commonly used at 10 μM. NBQX disodium salt from Hello Bio inhibits spontaneous and evoked excitatory post synaptic currents (EPSCs) (see Fig 1 above). Complete AMPA receptor blockade was achieved at 10 μM and NBQX disodium salt was also effective at reducing these currents at 1 μM.
#Protocol 1: Evoked and spontaneous excitatory post synaptic currents (EPSCs)
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Solubility & Handling
Storage instructions | -20°C |
Solubility overview | Soluble in water (100mM) |
Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
Chemical name | 2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide disodium salt |
Molecular Weight | 380.24 |
Chemical structure | |
Molecular Formula | C12H6N4Na2O6S |
CAS Number | 479347-86-9 |
PubChem identifier | 3272523 |
SMILES | [Na+].[Na+].NS(=O)(=O)c3cccc2c3c(cc1nc([O-])c([O-])nc12)[N+]([O-])=O |
Source | Synthetic |
InChi | InChI=1S/C12H8N4O6S.2Na/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6;;/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22);;/q;2*+1/p-2 |
InChiKey | SVJKYIUJRJEABK-UHFFFAOYSA-L |
MDL number | MFCD12910445 |
Appearance | Orange solid |
References for NBQX disodium salt
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It is AMPA receptor, not kainate receptor, that contributes to the NBQX-induced antinociception in the spinal cord of rats.
Kong LL et al (2006) Brain Res 1100(1) : 73-7. -
Pharmacological characterization of glutamatergic agonists and antagonists at recombinant human homomeric and heteromeric kainate receptors in vitro.
Alt et al (2004) Neuropharmacology 46(6) : 793-806 -
Both MK801 and NBQX reduce the neuronal damage after impact-acceleration brain injury.
Goda M et al (2002) J Neurotrauma 19(11) : 1445-56. -
Antiepileptogenic and anticonvulsant effects of NBQX, a selective AMPA receptor antagonist, in the rat kindling model of epilepsy.
Namba T et al (1994) Brain Res 638(1-2) : 36-44. -
Competitive inhibition by NBQX of kainate/AMPA receptor currents and excitatory synaptic potentials: importance of 6-nitro substitution.
Randle JC et al (1992) Eur J Pharmacol 215(2-3) : 237-44.
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PAR1 activation induces rapid changes in glutamate uptake and astrocyte morphology.
Sweeny et al (2017) Sci Rep. 7 : 43606PubMedID: 28256580 -
mGluR-LTD at Excitatory and Inhibitory Synapses in the Lateral Habenula Tunes Neuronal Output.
Valentinova and Mameli ( 2016) Cell Rep 16(9) : 2298-307PubMedID: 27545888