Product overview
| Name | DL-AP5 |
| Description | Competitive NMDA receptor antagonist |
| Alternative names | DL-APV |
| Purity | >99% |
| Customer comments | DL-AP5: can't get a better deal than this! We love Hello Bio's DL-AP5!! This is one of the most heavily used inhibitors in our electrophysiology lab and with three rigs running daily we go through a LOT of it... Verified customer, University of Toronto |
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Biological Data
| Biological description | DL-AP5 is a competitive NMDA receptor antagonist which binds at the glutamate site. Impairs learning and fear conditioning. Water soluble DL-AP5 sodium salt also available. |
| Application notes | DL-AP5 from Hello Bio reduces the evoked NMDAR current at concentrations of 1 and 10 μM with full receptor antagonism achieved at 50 μM (see Fig 1 above). It was dissolved in water at 10 mM.
#Protocol 1: Evoked NMDA receptor currents
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Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in water (10mM) or 0.1M NaOH (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | DL-2-Amino-5-phosphonopentanoic acid |
| Molecular Weight | 197.13 |
| Chemical structure | ![DL-AP5 [76326-31-3] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0251.png "DL-AP5 [76326-31-3]") |
| Molecular Formula | C5H12NO5P |
| CAS Number | 76326-31-3 |
| PubChem identifier | 1216 |
| SMILES | NC(CCCP(=O)(O)O)C(=O)O |
| Source | Synthetic |
| InChi | InChI=1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11) |
| InChiKey | VOROEQBFPPIACJ-UHFFFAOYSA-N |
| MDL number | MFCD00010515 |
| Appearance | White solid |
References for DL-AP5
References are publications that support the biological activity of the product
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Context-Dependent Modulation of Excitatory Synaptic Strength by Synaptically Released Zinc
Kalappa and Tzounopoulos (2017) eNeuro 10.1523 : 0011-17 -
Infusion of the NMDA receptor antagonist, DL-APV, into the basolateral amygdala disrupts learning to fear a novel and a familiar context as well as relearning to fear an extinguished context.
Laurent V et al (2009) Learn Mem 16(1) : 96-105. -
The basolateral amygdala is necessary for learning but not relearning extinction of context conditioned fear.
Laurent V et al (2008) Learn Mem 15(5) : 304-14. -
Comparative analysis of different competitive antagonists interaction with NR2A and NR2B subunits of NMDA ionotropic glutamate receptor.
Blaise MC et al (2005) J Mol Model 11(6) : 489-502.
Publications
These publications cite the use of DL-AP5 purchased from Hello Bio:
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Long-Term Inactivation of Sodium Channels as a Mechanism of Adaptation in CA1 Pyramidal Neurons
Canavier et al (2022) bioRxiv https://doi.org/10.1101/2021.10.26.465936 : doi -
Theta-Burst Stimulation of Primary Afferents Drives Long-Term Potentiation in the Spinal Cord and Persistent Pain via α2σ-1-Bound NMDA Receptors
Huang Y et al (2022) J Neurosci 42(3) : 513-527PubMedID: 34880118 -
Ketamine induces opposite changes in AMPA receptor calcium permeability in the ventral tegmental area and nucleus accumbens
Skiteva O et al (2021) Transl Psychiatry 11(1) : 530PubMedID: 34650029 -
Nucleus Reuniens Afferents in Hippocampus Modulate CA1 Network Function via Monosynaptic Excitation and Polysynaptic Inhibition
Goswamee P et al (2021) Front Cell Neurosci 15 : 660897PubMedID: 34712120 -
NMDA receptors are altered in the substantia nigra pars reticulata and their blockade ameliorates motor deficits in experimental parkinsonism
Sitzia G et al (2020) Neuropharmacology 174 : 108136PubMedID: 32474027
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- Code:
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Selective, competitive NMDA receptor antagonist. Inhibits NMDAR-synaptic plasticity.