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BPAM344

(HB19154)
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Product overview

Name BPAM344
Alternative names BPAM
Purity >98%
Description

GluK2 kainate receptor positive allosteric modulator 

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews References (2)
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Biological Data

Biological description

GluK2 kainate receptor positive allosteric modulator (PAM) (EC50 values for potentiating the response of 100 uM kainate are 26.3 µM for GluK1, 75.4 µM for GluK2 and 639 µM for GluK3 respectively). BPAM344 stabilizes GluK2 in the closed state, inhibits kainate receptor desensitization and prolongs activation.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 4-Cyclopropyl-3,4-dihydro-7-fluoro-2H-1,2,4-benzothiadiazine 1,1-dioxide
Molecular Weight 242.27
Chemical structure BPAM344 | 1204572-55-3 Chemical Structure
Molecular Formula C10H11FN2O2S
CAS Number 1204572-55-3
PubChem identifier 67531324
SMILES FC1=CC=C(C2=C1)N(C3CC3)CNS2(=O)=O
Source Synthetic
InChi 1S/C10H11FN2O2S/c11-7-1-4-9-10(5-7)16(14,15)12-6-13(9)8-2-3-8/h1,4-5,8,12H,2-3,6H2
InChiKey FLTMTBPCYAZIKM-UHFFFAOYSA-N
Appearance White to off-white solid

References for BPAM344

References are publications that support the biological activity of the product

  • The positive allosteric modulator BPAM344 and L-glutamate introduce an active-like structure of the ligand-binding domain of GluK2.

    Bay Y et al (2024) FEBS letters 598 : 743-757
    Read more (PubMedID: 38369668)

  • Small-molecule positive allosteric modulation of homomeric kainate receptors GluK1-3: development of screening assays and insight into GluK3 structure.

    Bay Y et al (2024) The FEBS journal 291 : 1506-1529
    Read more (PubMedID: 38145505)

2 Item(s)

Related Products
Grouped product items
Order: HB19154
Pack PriceQty
10mg
$153
50mg
$585

GluK2 kainate receptor positive allosteric modulator 

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