Product overview
Name | Muscimol |
Description | Potent, selective, competitive GABAA receptor agonist |
Purity | >99% |
Images
Biological Data
Biological description | Potent, selective and competitive GABAA receptor agonist and a potent partial GABAA-ρ (GABAC) receptor agonist.
Muscimol enhances inhibitory neurotransmission and suppresses spontaneous activity. It is commonly used in reversible brain inactivation studies.
Shows psychoactive, memory impairing effects and anticonvulsant actions at high doses. |
Application notes | The GABAA receptor agonist muscimol is used at concentrations of 1-50 µM. Muscimol from Hello Bio used at 10 µM led to a large hyperpolarising whole-cell current in hippocampal CA1 neurons (see Fig 1 above). Action of muscimol was fully blocked by the GABAA receptor antagonist bicuculline (100 µM).
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Solubility & Handling
Storage instructions | Room temperature |
Solubility overview | Soluble in water (100mM) |
Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
Chemical name | 5-Aminomethyl-3-hydroxyisoxazole |
Molecular Weight | 114.1 |
Chemical structure | |
Molecular Formula | C4H6N2O2 |
CAS Number | 2763-96-4 |
PubChem identifier | 4266 |
SMILES | C1=C(ONC1=O)CN |
Source | Synthetic |
InChi | InChI=1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7) |
InChiKey | ZJQHPWUVQPJPQT-UHFFFAOYSA-N |
MDL number | MFCD00057894 |
Appearance | White solid |
References for Muscimol
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Muscimol as an Ionotropic GABA Receptor Agonist.
Johnston GA (2014) Neurochem Res 39(10) : 1942-7. -
Anticonvulsant and behavioral effects of muscimol in immature rats.
Mareš P et al (2014) Brain Res 1582 : 227-36. -
Hippocampal infusions of pyruvate reverse the memory-impairing effects of septal muscimol infusions.
Krebs DL et al (2005) Eur J Pharmacol 520(1-3) : 91-9.
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Non-invasive molecularly-specific millimeter-resolution manipulation of brain circuits by ultrasound-mediated aggregation and uncaging of drug carriers
Ozdas et al (2020) Nat Commun. 11(1) : 4929.PubMedID: 33004789 -
mGluR-LTD at Excitatory and Inhibitory Synapses in the Lateral Habenula Tunes Neuronal Output.
Valentinova and Mameli (2016) Cell Rep 16(9) : 2298-307PubMedID: 27545888