(-)-Bicuculline methobromide
Product overview
Name | (-)-Bicuculline methobromide |
Description | Prototypic, competitive GABAA receptor antagonist |
Alternative names | BIC |
Purity | >98% |
Images
Biological Data
Biological description | Methobromide salt form of (+)-bicuculline.
Also acts as a negative allosteric inhibitor of channel opening to inhibit GABAA receptor activation by anaesthetic agents.
Freebase, methiodide and methochloride salts also available. |
Application notes | The GABAA receptor antagonist bicuculline is commonly used to reduce levels of inhibition by blocking the actions of the neurotransmitter GABA. Bicuculline is commonly used at concentrations of 100 μM and above. Bicuculline methobromide from Hello Bio reduces both spontaneous inhibitory post synaptic currents (IPSC) and evoked IPSCs (see Fig 1 above). It was effective at concentrations of 1 mM with complete receptor blockade at 100 μM
#Protocol 1: Evoked and spontaneous inhibitory post synaptic currents (IPSCs)
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Solubility & Handling
Storage instructions | Room temperature |
Solubility overview | Soluble in water (50mM) |
Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
Chemical name | [R-(R*,S*)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide |
Molecular Weight | 462.3 |
Chemical structure | |
Molecular Formula | C21H20BrNO6 |
CAS Number | 73604-30-5 |
PubChem identifier | 171729 |
SMILES | C[N+]1(CCC2=CC3=C(C=C2C1C4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3)C.[Br-] |
InChi | InChI=1S/C21H20NO6.BrH/c1-22(2)6-5-11-7-15-16(26-9-25-15)8-13(11)18(22)19-12-3-4-14-20(27-10-24-14)17(12)21(23)28-19;/h3-4,7-8,18-19H,5-6,9-10H2,1-2H3;1H/q+1;/p-1 |
InChiKey | BWXCECYGGMGBHD-UHFFFAOYSA-M |
MDL number | MFCD00055149 |
Appearance | White solid |
References for (-)-Bicuculline methobromide
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Advantages of an antagonist: bicuculline and other GABA antagonists.
Johnston GA (2013) Br J Pharmacol 169(2) : 328-36. -
[Bicuculline inhibits airway remodeling in a murine model of chronic asthma].
Zhu T et al (2010) Nan Fang Yi Ke Da Xue Xue Bao 30(4) : 842-6. -
Differential effects of iontophoretic in vivo application of the GABA(A)-antagonists bicuculline and gabazine in sensory cortex.
Kurt S et al (2006) Hear Res 212(1-2) : 224-35.