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Biological Data

Biological description

Main endogenous inhibitory neurotransmitter. Activates ionotropic GABAA and GABAA-ρ receptors and metabotropic GABAB receptors. Also induces α-cell-mediated β-like endocrine cell neogenesis in vivo.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name 4-Aminobutyric acid
Molecular Weight 103.12
Chemical structure GABA  [56-12-2] Chemical Structure
Molecular Formula C4H9NO2
CAS Number 56-12-2
PubChem identifier 119
SMILES C(CC(=O)O)CN
InChi InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
InChiKey BTCSSZJGUNDROE-UHFFFAOYSA-N
MDL number MFCD00008226

References for GABA

References are publications that support the biological activity of the product
  • Long-Term GABA Administration Induces Alpha Cell-Mediated Beta-like Cell Neogenesis.

    Ben-Othman et al (2017) Cell. 168(1-2): : 73-85
  • Synthesis of neurotransmitter GABA via the neuronal tricarboxylic acid cycle is elevated in rats with liver cirrhosis consistent with a high GABAergic tone in chronic hepatic encephalopathy.

    Leke R et al (2011) J Neurochem 117(5) : 824-32.
  • GABA and GABA receptors in the central nervous system and other organs.

    Watanabe M et al (2002) Int Rev Cytol 213 : 1-47.
  • GABAc receptors: relatively simple transmitter -gated ion channels?

    Johnston GA (1996) Trends Pharmacol Sci 17(9) : 319-23.
  • GABA: a dominant neurotransmitter in the hypothalamus.

    Decavel C et al (1990) J Comp Neurol 302(4) : 1019-37.