Product overview
| Name | (+)-Bicuculline |
| Description | Prototypic, competitive GABAA receptor antagonist |
| Alternative names | BIC |
| Purity | >99% |
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Biological Data
| Biological description |
Prototypic, competitive GABAA receptor antagonist which displaces GABA from the agonist binding site to prevent receptor activation. Also acts as a negative allosteric inhibitor of channel opening to inhibit GABAA receptor activation by anaesthetic agents.
Water soluble methiodide, methochloride and methobromide salts also available. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (100mM) |
| Handling | Rapid hydrolysis may occur in solutions made with aqueous acid. You should therefore make and use these within 1 hour. |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | [R-(R*,S*)]-6-(5,6,7,8-Tetrahydro-6 -methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3, 4-e]-1,3-benzodioxol-8(6H)-one |
| Molecular Weight | 367.36 |
| Chemical structure |  |
| Molecular Formula | C20H17NO6 |
| CAS Number | 485-49-4 |
| PubChem identifier | 10237 |
| SMILES | CN1CCC2=CC3=C(C=C2[C@H]1[C@H]4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3 |
| InChi | InChI=1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1 |
| InChiKey | IYGYMKDQCDOMRE-ZWKOTPCHSA-N |
| MDL number | MFCD00005006 |
| Appearance | Yellow solid |
References for (+)-Bicuculline
References are publications that support the biological activity of the product
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Advantages of an antagonist: bicuculline and other GABA antagonists.
Johnston GA (2013) Br J Pharmacol 169(2) : 328-36. -
[Bicuculline inhibits airway remodeling in a murine model of chronic asthma].
Zhu T et al (2010) Nan Fang Yi Ke Da Xue Xue Bao 30(4) : 842-6. -
Differential effects of iontophoretic in vivo application of the GABA(A)-antagonists bicuculline and gabazine in sensory cortex.
Kurt S et al (2006) Hear Res 212(1-2) : 224-35.
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