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Images (+)-Bicuculline product vial image | Hello Bio
(+)-Bicuculline product vial image | Hello Bio Biological Data Biological description
Prototypic, competitive GABAA receptor antagonist which displaces GABA from the agonist binding site to prevent receptor activation.
Also acts as a negative allosteric inhibitor of channel opening to inhibit GABAA receptor activation by anaesthetic agents.
A receptor mediated currents. Widely used to isolate glutamate receptor mediated EPSCs (excitatory postsynaptic potentials).
Water soluble methiodide , methochloride and methobromide salts also available.
Solubility & Handling Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM)
Handling Rapid hydrolysis may occur in solutions made with aqueous acid. You should therefore make and use these within 1 hour.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name [R-(R *,S *)]-6-(5,6,7,8-Tetrahydro-6 -methyl-1,3-dioxolo[4,5-g ]isoquinolin-5-yl)furo[3, 4-e ]-1,3-benzodioxol-8(6H )-one
Chemical structure
Molecular Formula C20 H17 NO6
SMILES CN1CCC2=CC3=C(C=C2[C@H]1[C@H]4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3
InChi InChI=1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1
InChiKey IYGYMKDQCDOMRE-ZWKOTPCHSA-N
References for (+)-Bicuculline References are publications that support the biological activity of the product
Advantages of an antagonist: bicuculline and other GABA antagonists. Johnston GA (2013) Br J Pharmacol 169(2) : 328-36. [Bicuculline inhibits airway remodeling in a murine model of chronic asthma]. Zhu T et al (2010) Nan Fang Yi Ke Da Xue Xue Bao 30(4) : 842-6. Differential effects of iontophoretic in vivo application of the GABA(A)-antagonists bicuculline and gabazine in sensory cortex. Kurt S et al (2006) Hear Res 212(1-2) : 224-35.
Publications
These publications cite the use of (+)-Bicuculline purchased from Hello Bio:
Voltage tunes mGlu5 receptor function, impacting synaptic transmission Perroy et al (2023) bioRxiv https://www.biorxiv.org/content/10.1101/2023.07.17.549279v1.abstract
Distinct Functional Alterations and Therapeutic Options of Two Pathological De Novo Variants of the T292 Residue of GABRA1 Identified in Children with Epileptic Encephalopathy and Neurodevelopmental Disorders Chen W et al (2022) Int J Mol Sci 23(5) PKA drives an increase in AMPA receptor unitary conductance during LTP in the hippocampus Park P et al (2021) Nat Commun 12(1) : 413 Vangl2 in the Dentate Network Modulates Pattern Separation and Pattern Completion Robert BJA et al (2020) Cell Rep 31(10) : 107743 La potenciación del receptor de glicina por etanol en neuronas D1 MSN del núcleo Accumbens regula el consumo y preferencia por etanol. Gallegos et al (2020) UdeC : Thesis
Prototypic, competitive GABAA receptor antagonist
![(+)-Bicuculline [485-49-4] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0896.png "(+)-Bicuculline [485-49-4]")
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