Product overview

Name (+)-Bicuculline
Description Prototypic, competitive GABAA receptor antagonist
Alternative names BIC
Purity >99%
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Biological Data

Biological description

Prototypic, competitive GABAA receptor antagonist which displaces GABA from the agonist binding site to prevent receptor activation. 

Also acts as a negative allosteric inhibitor of channel opening to inhibit GABAA receptor activation by anaesthetic agents.


Reversibly and competitively blocks GABAA receptor mediated currents. Widely used to isolate glutamate receptor mediated EPSCs (excitatory postsynaptic potentials).


Shows convulsant action and induces epilepsy.

Water soluble methiodidemethochloride and methobromide salts also available.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM)
Handling Rapid hydrolysis may occur in solutions made with aqueous acid. You should therefore make and use these within 1 hour.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name [R-(R*,S*)]-6-(5,6,7,8-Tetrahydro-6 -methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3, 4-e]-1,3-benzodioxol-8(6H)-one
Molecular Weight 367.36
Chemical structure (+)-Bicuculline  [485-49-4] Chemical Structure
Molecular Formula C20H17NO6
CAS Number 485-49-4
PubChem identifier 10237
SMILES CN1CCC2=CC3=C(C=C2[C@H]1[C@H]4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3
InChi InChI=1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1
InChiKey IYGYMKDQCDOMRE-ZWKOTPCHSA-N
MDL number MFCD00005006
Appearance Yellow solid

References for (+)-Bicuculline

References are publications that support the biological activity of the product
  • Advantages of an antagonist: bicuculline and other GABA antagonists.

    Johnston GA (2013) Br J Pharmacol 169(2) : 328-36.
  • [Bicuculline inhibits airway remodeling in a murine model of chronic asthma].

    Zhu T et al (2010) Nan Fang Yi Ke Da Xue Xue Bao 30(4) : 842-6.
  • Differential effects of iontophoretic in vivo application of the GABA(A)-antagonists bicuculline and gabazine in sensory cortex.

    Kurt S et al (2006) Hear Res 212(1-2) : 224-35.