|Description|| Prototypic, competitive GABAA receptor antagonist |
Prototypic, competitive GABAA receptor antagonist which displaces GABA from the agonist binding site to prevent receptor activation.
Also acts as a negative allosteric inhibitor of channel opening to inhibit GABAA receptor activation by anaesthetic agents.
Reversibly and competitively blocks GABAA receptor mediated currents. Widely used to isolate glutamate receptor mediated EPSCs (excitatory postsynaptic potentials).
Shows convulsant action and induces epilepsy.
Water soluble methiodide, methochloride and methobromide salts also available.
Solubility & Handling
|Storage instructions|| +4°C |
|Solubility overview|| Soluble in DMSO (100mM) |
|Handling|| Rapid hydrolysis may occur in solutions made with aqueous acid. You should therefore make and use these within 1 hour. |
|Important|| This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
|Chemical name|| [R-(R*,S*)]-6-(5,6,7,8-Tetrahydro-6 -methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3, 4-e]-1,3-benzodioxol-8(6H)-one |
|Chemical structure|| |
|Molecular Formula|| C20H17NO6 |
|SMILES|| CN1CCC2=CC3=C(C=C2[C@H]1[C@H]4C5=C(C6=C(C=C5)OCO6)C(=O)O4)OCO3 |
|InChi|| InChI=1S/C20H17NO6/c1-21-5-4-10-6-14-15(25-8-24-14)7-12(10)17(21)18-11-2-3-13-19(26-9-23-13)16(11)20(22)27-18/h2-3,6-7,17-18H,4-5,8-9H2,1H3/t17-,18+/m0/s1 |
|InChiKey|| IYGYMKDQCDOMRE-ZWKOTPCHSA-N |
References for (+)-Bicuculline
References are publications that support the biological activity of the product
Advantages of an antagonist: bicuculline and other GABA antagonists.
Johnston GA (2013) Br J Pharmacol 169(2) : 328-36.
[Bicuculline inhibits airway remodeling in a murine model of chronic asthma].
Zhu T et al (2010) Nan Fang Yi Ke Da Xue Xue Bao 30(4) : 842-6.
Differential effects of iontophoretic in vivo application of the GABA(A)-antagonists bicuculline and gabazine in sensory cortex.
Kurt S et al (2006) Hear Res 212(1-2) : 224-35.