Kynurenic acid sodium salt
(HB0363)
Product overview
Name | Kynurenic acid sodium salt |
Description | Endogenous ionotropic glutamate / nicotinic antagonist. Sodium salt. |
Purity | >98% |
Customer comments | Good and convenient. The substance we purchased (Kynurenic acid sodium salt) showed good chemical quality and much more convenient in respect to other sellers. Ordering is very easy and shipment is fast and safe. Verified customer, Unife |
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Biological Data
Biological description | Endogenous, non-selective ionotropic glutamate receptor antagonist which acts as a non-competitive glycine site NMDAR antagonist. Also an α7 nicotinic receptor antagonist and GPR35 ligand. Sodium salt. Blocks kainic acid neurotoxicity and displays neuroprotective, antiproliferative and antimigrative properties. |
Application notes | Kynurenic acid is commonly used as an AMPA/NMDA receptor antagonist. Kynurenic acid is commonly used at concentration of 10mM. Kynurenic acid from Hello Bio rapidly inhibits both NMDA and AMPA mediated spontaneous and evoked EPSCs at concentrations of 10mM (see Fig 1 above).
#Protocol 1: Evoked NMDA receptor currents
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Solubility & Handling
Storage instructions | Room temperature (desiccate) |
Solubility overview | Soluble in water (100mM) or DMSO (50mM) |
Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
Chemical name | 4-Hydroxyquinoline-2-carboxylic acid sodium salt |
Molecular Weight | 211.15 |
Chemical structure | |
Molecular Formula | C10H6NNaO3 |
CAS Number | 2439-02-3 |
PubChem identifier | 52974250 |
SMILES | C1=CC=C2C(=C1)C(=O)C=C(N2)C(=O)[O-].[Na+] |
Source | Synthetic |
InChi | InChI=1S/C10H7NO3.Na/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9;/h1-5H,(H,11,12)(H,13,14);/q;+1/p-1 |
InChiKey | RCAZGXKUQDXSSK-UHFFFAOYSA-M |
MDL number | MFCD00006753 |
Appearance | Pale solid |
References for Kynurenic acid sodium salt
References are publications that support the biological activity of the product
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Kynurenic acid inhibits proliferation and migration of human glioblastoma T98G cells.
Walczak K et al (2014) Pharmacol Rep 66(1) : 130-6. -
Pharmacological characterization of glutamatergic agonists and antagonists at recombinant human homomeric and heteromeric kainate receptors in vitro.
Alt et al (2004) Neuropharmacology 46(6) : 793-806 -
6-Hydroxykynurenic acid and kynurenic acid differently antagonise AMPA and NMDA receptors in hippocampal neurones.
Weber M et al (2001) J Neurochem 77(4) : 1108-15. -
Kynurenate is neuroprotective following experimental brain injury in the rat.
Hicks RR et al (1994) Brain Res 655(1-2) : 91-6.