Calcium Ionophore A23187 product vial image | Hello Bio
Calcium Ionophore A23187 product vial image | Hello Bio
Biological Data
Biological description
Non-selective calcium ionophore which facilitates transport of Ca2+ across the plasma membrane.
Increases intracellular Ca2+ concentration to induce Ca2+-dependent cell death. Also increases Zn2+ and Fe2+ permeability across the cell membrane.
Induces ROS and oxidative platelet particle formation.
Also activates IKK2 and NF-κB in mast cells, induces cytokine production and degranulation.
Additionally shown to induce apoptosis and autophagy.
Solubility & Handling
Solubility overview
Soluble in DMSO (50mM) and in ethanol (10mM, gentle warming)
Storage instructions
+4°C (desiccate)
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Platelet particle formation by anti GPIIIa49-66 Ab, Ca2+ ionophore A23187, and phorbol myristate acetate is induced by reactive oxygen species and inhibited by Dex blockade of platelet phospholipase A2, 12-lipoxygenase, and NADPH oxidase.
![A23187 [52665-69-7] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1000.png "A23187 [52665-69-7]")
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