Calcium Ionophore A23187

(HB1000)
Technical documents: SDS Datasheet

Product overview

Name Calcium Ionophore A23187
Description Non-selective calcium ionophore
Alternative names Calcimycin
Purity >98%
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Biological Data

Biological description

Non-selective calcium ionophore which facilitates transport of Ca2+ across the plasma membrane.

Increases intracellular Ca2+ concentration to induce Ca2+-dependent cell death. Also increases Zn2+ and Fe2+ permeability across the cell membrane.

Induces ROS and oxidative platelet particle formation.

Also activates IKK2 and NF-κB in mast cells, induces cytokine production and degranulation.

Additionally shown to induce apoptosis and autophagy.

Solubility & Handling

Storage instructions +4°C (desiccate)
Solubility overview Soluble in DMSO (50mM) and in ethanol (10mM, gentle warming)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name 5-(Methylamino)-2-[[2R,3R,6S,8S,9R,11R)-3,9,11-trimethyl-8-[(1S)-1-methyl-2-oxo-2-(1H-pyr rol-2-yl)-ethyl]-1,7-dioxaspiro[5.5]undec-2-yl]methyl]-4-benzoxazolecarboxylic acid
Molecular Weight 523.63
Chemical structure A23187  [52665-69-7] Chemical Structure
Molecular Formula C29H37N3O6
CAS Number 52665-69-7
PubChem identifier 40486
SMILES C[C@H]1CCC2([C@@H](C[C@H]([C@H](O2)C(C)C(=O)C3=CC=CN3)C)C)O[C@H]1CC4=NC5=C(O4)C=CC(=C5C(=O)O)NC
InChi InChI=1S/C29H37N3O6/c1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35/h6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35)/t15-,16+,17+,18?,22-,27-,29?/m0/s1
InChiKey HIYAVKIYRIFSCZ-CVXKHCKVSA-N
MDL number MFCD00151202

References for Calcium Ionophore A23187

References are publications that support the biological activity of the product
  • Role of calcium ionophore A23187-induced activation of IkappaB kinase 2 in mast cells.

    Hosokawa J et al (2013) Int Arch Allergy Immunol 161 Suppl 2 : 37-43.
  • Zn(2+), derived from cell preparation, partly attenuates Ca(2+)-dependent cell death induced by A23187, calcium ionophore, in rat thymocytes.

    Sakanashi Y et al (2009) Toxicol In Vitro 23(2) : 338-45.
  • Platelet particle formation by anti GPIIIa49-66 Ab, Ca2+ ionophore A23187, and phorbol myristate acetate is induced by reactive oxygen species and inhibited by Dex blockade of platelet phospholipase A2, 12-lipoxygenase, and NADPH oxidase.

    Nardi MA et al (2007) Blood 110(6) : 1989-96.
Publications
These publications cite the use of Calcium Ionophore A23187 purchased from Hello Bio:
  • Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18.

    Lai et al (2017) Neuron. 95(3) : 591-607
    PubMedID: 28772123

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