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Cyclopiazonic acid

(HB1117)
Publications (1)
Technical documents: SDS CoA Datasheet
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Product overview

Name Cyclopiazonic acid
Alternative names α-Cyclopiazonic acid, CPA
Purity >98%
Description Potent SERCA1a inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews Publications (1) References (2) Frequently bought together
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Biological Data

Biological description Potent sarcoplasmic reticulum Ca2+ -ATPase 1a (SERCA1a) inhibitor. Also inhibits cell proliferation but is 40 times less potent than ochratoxin A (approx IC50 = 52 µM).

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in ethanol (5mM) or DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name (6aR,11aS,11bR)-rel-10-Acetyl-2,6,6 a,7,11a,11b-hexahydro-7,7-dimethyl-9H-pyrrolo[1',2': 2,3]isoindolo[4,5,6-cd]indol-9-one
Molecular Weight 336.39
Chemical structure Cyclopiazonic acid [18172-33-3] Chemical Structure
Molecular Formula C20H20N2O3
CAS Number 18172-33-3
PubChem identifier 54682463
SMILES CC(=O)C1=C([C@@H]2[C@@H]3[C@@H](CC4=C5C3=CNC5=CC=C4)C(N2C1=O)(C)C)O
InChi InChI=1S/C20H20N2O3/c1-9(23)14-18(24)17-16-11-8-21-13-6-4-5-10(15(11)13)7-12(16)20(2,3)22(17)19(14)25/h4-6,8,12,16-17,21,24H,7H2,1-3H3/t12-,16+,17+/m1/s1
InChiKey SZINUGQCTHLQAZ-DQYPLSBCSA-N
MDL number MFCD00167445

References for Cyclopiazonic acid

References are publications that support the biological activity of the product

  • Probing determinants of cyclopiazonic acid sensitivity of bacterial Ca2+-ATPases.

    Kotšubei A et al (2013) FEBS J 280(21) : 5441-9.
    Read more (PubMedID: 23621633)

  • The effects of the Penicillium mycotoxins citrinin, cyclopiazonic acid, ochratoxin A, patulin, penicillic acid, and roquefortine C on in vitro proliferation of porcine lymphocytes.

    Keblys M et al (2004) Mycopathologia 158(3) : 317-24.
    Read more (PubMedID: 15702270)

2 Item(s)

Publications
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These publications cite the use of Cyclopiazonic acid purchased from Hello Bio:

  • Mechanisms Underlying Long-Term Synaptic Zinc Plasticity at Mouse Dorsal Cochlear Nucleus Glutamatergic Synapses

    Vogler NW et al (2020) J Neurosci 40(26) : 4981-4996
    PubMedID: 32434779

1 Item

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Grouped product items
Order: HB1117
Pack PriceQty
10mg
$95
50mg
$451
Potent SERCA1a inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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