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Biological Data Biological description Potent and non-competitive sarco-endoplasmic Ca2+ -ATPase (SERCA) inhibitor. Activates endoplasmic reticulum stress mechanisms. Induces apoptosis in most cells. Shows anticancer and neuroprotective actions.
Solubility & Handling Storage instructions -20°C (desiccate)
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name (3S ,3aR ,4S ,6S ,6AR ,7S ,8S ,9bS )-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b- decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z )-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b ]furan-7-yl octanoate
Chemical structure
Molecular Formula C34 H50 O12
PubChem identifier 446378
SMILES CCCCCCCC(=O)O[C@H]1[C@H]2C(=C([C@@H]1OC(=O)/C(=C\C)/C)C)[C@H]3[C@]([C@H](C[C@]2(C)OC(=O)C)OC(=O)CCC)([C@](C(=O)O3)(C)O)O
InChi InChI=1S/C34H50O12/c1-9-12-13-14-15-17-24(37)43-28-26-25(20(5)27(28)44-30(38)19(4)11-3)29-34(41,33(8,40)31(39)45-29)22(42-23(36)16-10-2)18-32(26,7)46-21(6)35/h11,22,26-29,40-41H,9-10,12-18H2,1-8H3/b19-11-/t22-,26+,27-,28-,29-,32-,33+,34+/m0/s1
InChiKey IXFPJGBNCFXKPI-FSIHEZPISA-N
References for Thapsigargin References are publications that support the biological activity of the product
Targeting thapsigargin towards tumors. Doan NT et al (2014) Steroids : Targeting thapsigargin towards tumors. Doan NT et al (2014) Steroids : Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury: Involvement of PARK2-dependent mitophagy. Zhang X et al (2014) Autophagy 10(10) : 1801-13.
Potent, non-competitive SERCA inhibitor
![Thapsigargin [67526-95-8] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1118.png "Thapsigargin [67526-95-8]")
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