Product overview
| Name | Thapsigargin |
| Description | Potent, non-competitive SERCA inhibitor |
| Purity | >97% |
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Biological Data
| Biological description | Potent and non-competitive sarco-endoplasmic Ca2+-ATPase (SERCA) inhibitor. Activates endoplasmic reticulum stress mechanisms. Induces apoptosis in most cells. Shows anticancer and neuroprotective actions. |
Solubility & Handling
| Storage instructions | -20°C (desiccate) |
| Solubility overview | Soluble in DMSO (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | (3S,3aR,4S,6S,6AR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b- decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl octanoate |
| Molecular Weight | 650.76 |
| Chemical structure | ![Thapsigargin [67526-95-8] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1118.png "Thapsigargin [67526-95-8]") |
| Molecular Formula | C34H50O12 |
| CAS Number | 67526-95-8 |
| PubChem identifier | 446378 |
| SMILES | CCCCCCCC(=O)O[C@H]1[C@H]2C(=C([C@@H]1OC(=O)/C(=C\C)/C)C)[C@H]3[C@]([C@H](C[C@]2(C)OC(=O)C)OC(=O)CCC)([C@](C(=O)O3)(C)O)O |
| InChi | InChI=1S/C34H50O12/c1-9-12-13-14-15-17-24(37)43-28-26-25(20(5)27(28)44-30(38)19(4)11-3)29-34(41,33(8,40)31(39)45-29)22(42-23(36)16-10-2)18-32(26,7)46-21(6)35/h11,22,26-29,40-41H,9-10,12-18H2,1-8H3/b19-11-/t22-,26+,27-,28-,29-,32-,33+,34+/m0/s1 |
| InChiKey | IXFPJGBNCFXKPI-FSIHEZPISA-N |
| MDL number | MFCD00083511 |
References for Thapsigargin
References are publications that support the biological activity of the product
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Targeting thapsigargin towards tumors.
Doan NT et al (2014) Steroids : -
Targeting thapsigargin towards tumors.
Doan NT et al (2014) Steroids : -
Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury: Involvement of PARK2-dependent mitophagy.
Zhang X et al (2014) Autophagy 10(10) : 1801-13.
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