Clozapine dihydrochloride (water soluble)

Water soluble clozapine is a prototypic, atypical antipsychotic which binds to both serotonin and dopamine receptors (K_i values are 35, 83 and 22, 250 and 141 nM at D₂, D₃ and D₄, D₅, D₁ and 12.6 and 13.2 nM at 5-HT_2A and 5-HT_2C receptors respectively) and also shows activity at other receptors.

Clozapine shows high BBB permeability and is active in vivo. It shows antipsychotic, antidepression and anxiolytic activites.

Recently, clozapine (which CNO rapidly converts to) has been indicated to show high DREADD (hM3Dq and hM4Di) affinity and potency. Subthreshold clozapine injections are indicated to induce preferential DREADD-mediated behaviors.

Clozapine also available

Storage of solid

• Store at -20°C.
• Please note that the compound is a hydroscopic solid and contact with air may cause material to become sticky. Product performance should not be affected but we recommend storing the material in a sealed jar.

Storage of solutions

• Make up solutions and use immediately.
• If storage of solutions is required, you should aliquot out the solution into tightly sealed vials and store at -20°C and store these for up to one month.
• Allow the product to equilibrate to RT for at least one hour before opening and using.


Storage of solutions at room temperature

• We recommend only keeping solutions at room temperature (25°C) for a few days as our studies have shown that after 96 hours the purity of the compound in solution drops to ~95% and will continue to drop over time.

C₁₈H₁₉ClN₄ · 2HCl